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In the human body, stem cells are located in niches, which are extremely complex microenvironments (with specified oxygen conditions and cellular together with extracellular matrix components arranged as a 3D structure). The influence of signals from niches seems to play an important role in maintenance of stem cells pluripotency and in their differentiation. We have been investigating the influence...
Epigenetic cues are potent tools for in vitro control of the stem cell fate decisions. Since human iPSc, can be derived from any tissue of the body and are characterized by unlimited self-renewal and potential to differentiation into all cell types of the body, they are considered as a good source for autologous transplantation. In this report we were studying the process of induction of pluripotency...
The oligodendrocyte precursors exhibit many features of neural stem cells and constitute the abundant population of dividing progenitors in the young and adult brain. A question arises if their commitment and development could be modulated by either local tissue-specific or neuropathological signals. The aim of our study was to evaluate the effect of distinct microenvironments (provided by either...
The Embryonic Stem Cells (ESCs) are characterized by unlimited self-renewal ability and potential to differentiate into all cell types of the body. Those cells are derived from embryos which reside in 3-5 % oxygen environment. This hypoxic condition is physiologically normal not only for ES cells but also for many other types of stem cells, for example Neural Stem Cells. These observations suggest...
Induced pluripotent stem cells (iPSCs) are the product of somatic cell reprogramming into an undifferentiated embryonic-like state. These pluripotent cells might adopt various phenotypes by means of bioengineering methods and therefore might serve for disease modeling, pharmaceutical screening and cellular replacement therapies. Transcription factors such as Oct4, Sox2, Klf4 and Myc play the crucial...
W pracy przedstawiono możliwości diagnostyki i terapii kardiologicznej wykorzystujące techniki nieinwazyjnej elektrostymulacji serca, prowadzonej z użyciem wielofunkcyjnego urządzenia DiagnoStim MDD-501. Na przykładach pacjentów, u których urządzenie spełniło jednocześnie funkcję diagnostyczną i terapeutyczną oraz pacjentów, u których diagnostyczne możliwości urządzenia zadecydowały o wdrożeniu lub...
Brain infl ammation contributes to the propagation of neuropathological events that involves activation of astrocytes and microglia. It remains obscure how activated glial cells affect the survival and differentiation of neural stem cells (NSC). The aim of the study was to analyze neuronal commitment of Human Umbilical Cord Blood derived Neural Stem Cells (HUCB-NSC) cultured in the presence of normal...
W pracy opisano przebieg realizacji oraz uzyskane do chwili obecnej wyniki projektu EUREKA! „CARDISCREEN”, podjętego w celu opracowania, standaryzacji i weryfikacji nowej metody diagnostycznej bazującej na kardiostymulacji nieinwazyjnej i elektrokardiografii. Metoda ta umożliwi wykrycie potencjalnego ryzyka wystąpienia choroby wieńcowej w badaniach przesiewowych osób z populacji zagrożonej.
The main purpose of this study was to determine if fenugreek (Trigonella foenum graecum L.) seeds extract (FSE ) and lucerne (Medicago sativa L.) extract (LDE) modulate post-challenge carbohydrate metabolism in type 2 diabetes animal model. Type 2 diabetes was induced in the Wistar rat neonates by intraperitoneal administration of streptozotocin. Experimental animals (60) were divided into following...
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