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INTRODUCTION: The endocannabinoid system (ECS) is composed of cannabinoid (CB: CB1 and CB2) receptors and endocannabinoids, which are degraded by fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Thus, the function of the ECS might be modulated in a direct way, through CB receptor ligands or indirectly by FAAH and MAGL inhibitors. The ECS system is involved in many physiological functions,...
INTRODUCTION: Posttraumatic stress disorder (PTSD) is a chronic and prevalent psychiatric condition that may develop following exposure to traumatic events. Depressive symptoms and anxiety belong to the most frequent symptoms observed in PTSD patients. Less than 30% of PTSD patients achieve full remission with the use of available drugs. For this purpose, there is a clear need to develop more efficient...
Addiction is a chronic psychiatric disease which represents a global problem, and stress can increase drug addiction and relapse. Taking into account frequent concomitance of nicotine dependence and stress, the purpose of the present study was to assess behavioral and biochemical effects of chronic unpredictable mild stress (CUMS) exposure on nicotine reward in rats measured in the conditioned place...
Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with chronic unpredictable mild stress (CUMS). Mice were submitted to the procedure of...
3,4-Methylenedioxymethamphetamine (MDMA, ‘ecstasy’), a potent monoamine-releaser that is widely used as a recreational drug. Hence, understanding the effects and mechanisms of MDMA is of immense importance for the public health in the world. We examined how an acute dose of MDMA affects memory and learning processes, anxiety- and depressive-like behaviors in female Swiss mice as well as oxidative...
Cannabinoids are implicated in regulation of variety emotions through the type 1 (CB1) and type 2 (CB2) receptors. Our pharamcological interests have been focused on the effects of CB2 receptor selective ligands in the treatment of Alzheimer disease (AD) which is associated with memory-loss, phobia, depression as well as oxidative processes in brain. We examined the impact of CB2 agonist: JWH-133...
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