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Purpose: The assessment of the antifungal activity of 59 new synthesized compounds. We compared the antifungal activity of N,N-phenyl-1,2,3,4-thiatriazole-5-yl-2,4-b-resorcyl-carbothioamide (PTR), of n-3-(1,2,4-dithiazole-5-thione)--reso-rcylcarbothioamide (DTRTA), of N,N-phenyl-1,2,3,4-thiatriazol-5-yl-2,4-b-resorcyl-carbothio-amide (PHARA) against Candida albicans strains in vitro. Material and...
The retention behaviour of eighteen new antifungal dihydroxythiobenzanilides in a reversed-phase high performance thin-layer chromatographic system has been examined. Using water-acetone as the mobile phase, a linear relationship between the volume fraction of the organic solvent and the log k' values over a limited range was established for every solute. The physico-chemical parameters of these compounds...
Studies were the effect of 2,4,6-trihydroxybenzenocarboditioic acid (TBCD) on unpurified enzymatic extract of aconitate hydratase from Aspergillus niger fungi. The inhibition of aconitate hydratase functions, by means of estimation of regulation extent of equilibrium isomerization reactions of citrates under influence of TBCD, was found.
In laboratory plate studies on the effect of L-histidine on the fungistatic action of 2,4,6- trihydroxybenzencarboditioic acid (TBKD) was recorded. A gradual increase of concentration of L-histidine in the mineral medium at first weakens and then increases inhibitory properties of the system. The mechanism of the molecular co-operation of the amino acid was also discussed.
While searching for the directions of synthesis of compounds with plant growth regulation properties, an estimation was done of the substituent effect at the carbamate nitrogen atom upon compounds of the carbamate series. It was found that the introduction of α-naphtyl substitution produces specific induction effects and izomerization rearrangements that do not favour biological activity. In the postemergence...
Studies on reaction equilibria of Fe3+ ions complexing a diligand system of citric and 2,4,6-trihydroxybenzencarboditioid acid (a fungicidal compound of inhibitors of respiration processes) were carried out. On this ground a hypothetical mechanism of action of those compounds upon enzymatic substrates of aconitane hydratase in the cycle of tricarboxylic acids was proposed.
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