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Cross-linking of cell surface receptors by multivalent ligands, e.g. by antibodies, evokes their clustering - patching. Subsequently, these clusters can be translocated by the acto-myosin machinery toward one pole of the cell and assembly cap. Patching of FcγRII in U937 cells correlates with tyrosine phosphorylation of several proteins while cap assembly correlates with their dephosphorylation. To...
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