The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Based on the 3D conformation of the N-terminus of TMOF in solution, six aromatic derivatives of enoic acid: 7-biphenyl-4-yl-hept-4-enoic acid (BPHE), 7-(4-butyl-phenyl)-hept-4-enoic acid (BuPHE), 7-cyclohexyl-hept-4-enoic acid (CyHE), 10-phenyl-dec-7-enoic acid (PDE), 7-p-tolyl-hept-2-enoic acid ethyl ester (THEEE) and 7-(4-methoxy-phenyl)-hept-2-enoic acid ethyl ester (MPEEE) were computer-modeled...
The binding of TMOF to its gut receptor was followed by incubating guts removed from male and female Aedes aegypti. TMOF at physiological concentrations, in the presence of [γ32P]ATP, causes phosphorylation and release of gut-membrane protein (45 kDa) that is further processed by proteolysis. In the presence of protease inhibitors only the 45 kDa protein was released. The phosphorylation and processing...
Trypsin Modulating Oostatic Factor from the mosquito, Aedes aegypti, (Aea-TMOF) inhibits juvenile hormone (JH) - stimulated egg chorionation and patency in the follicular epithelium cells of Heliothis virescens. Aea-TMOF exhibits highest inhibitory effect on oocytes or follicular epithelium cells when it is administered together with JH I rather than with JH III. These results indicate that Aea-TMOF...
The three-dimensional conformation of Aea-TMOF (Aedes aegypti Trypsin Modulating Oostatic Factor), a decapeptide (YDPAPPPPPP) isolated from mosquito ovaries that inhibits the translation of many trypsin-like serine proteases, e.g. in mosquitoes, flies and lepidopterans, was used as a model for the synthesis of 10 aromatic and aliphatic organic acid and ester analogues. The organic TMOF analogues were...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.