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Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies...
The aim of the cross-sectional study was to establish the degree of conformity between 10-year probability of osteoporotic fracture, assessed by FRAX, and using the nomograms, as proposed by Nguyen at al.Postmenopausal Polish women (2012) were examined in their mean age of 68.5±7.9years (age range 55–90years). Fracture probability by FRAX was based on age, BMI, prior fracture, hip fracture in parents,...
Thymidine phosphorylase (dThdPase; EC 2.4.2.4) is an enzyme catalyzing the reversible phosphorolysis of thymidine, deoxyuridine and of their analogues to the respective bases and to 2-deoxyribose-1-phosphate. Thymidine phosphorylase also catalyzes a deoxyribosyltransfer from one deoxynucleoside to another base, to form the second deoxynucleoside. A high activity of dThdPase is observed in malignant...
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