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Shaker-related Kv1.3 channels are the most prevalent and widely studied ion channels in normal human T Lymphocytes (TL) as well as in certain T cell lines, such as Jurkat cells. This review focuses on modulatoty effects of intracellular cAMP on the activity of the channels. Available data provide evidence that: 1) intracellular cAMP directly activates a novel class of charybdotoxin-insensitive voltage-independent...
The aim of our study was to clarify the still controversial problem concerning the modulatory effect of β-adrenergic stimulation on the activity of Kv1.3 channels in human T Lymphocytes. Because the expression of β-adrenergic receptors in T Lymphocytes is significantly altered in patients with bronchial asthma we examined the cells taken both from healthy donors and asthmatic patients. We applied...
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