The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Evidence suggests that maternal immune activation (MIA) during pregnancy is a risk factor for neurodevelopmental disturbances including autism spectrum disorders (ASDs). Animal models support this linkage and demonstrate that MIA in rodents leads to behavioral alterations in offspring that are characteristic of autism. However, the mechanism by which MIA causes long‑term behavioral deficits is unknown...
INTRODUCTION: Prenatal exposure to infection and subsequent inflammatory responses, as well as, mitochondrial dysfunction has been implicated in the pathogenesis of autism spectrum disorders (ASDs). However, the molecular links between infection-induced fetal brain changes, mitochondrial deregulation, and the autistic phenotype remain obscure. AIM(S): Analysis of maternal immune activation (MIA)-induced...
Parkin and alpha‑synuclein (α‑syn) are two key proteins involved in the pathophysiology of Parkinson’s disease (PD). Oligomerization/ aggregation and excessive secretion of α‑syn contributes to PD through free radical stress, mitochondrial impairment, and synaptic dysfunction. Parkin, an E3 ubiquitin ligase, is considered to be a pleiotropic, neuroprotective protein that modulates metabolic turnover...
Purinergic signaling is involved in many neurodevelopmental alterations that eventually lead to severe disorders, such as autism spectrum disorders (ASD). It was suggested that metabolic pathways that synthesize and catabolize purines are critical regulatory elements in ASD and play a role in promoting behavioral abnormalities. However, the molecular basis of the altered purine metabolism in autism...
Autism spectrum disorders (ASDs) are among the most common neurodevelopmental diseases characterized by impairment in communication and social interaction along with stereotyped or repetitive behaviors. Multiple studies have highlighted the involvement of synaptic proteins in the pathogenesis of ASDs. AIM(S): The aim of this study was to investigate the effect of fetal exposure to valproic acid (VPA)...
In the study we investigated how current mood affects spontaneous perceptual processes of neutral stimuli of low‑arousal, unrelated to any specific task. Two separate but similar procedures were carried out: one using functional magnetic resonance imaging (fMRI), the other using electroencephalography based source localization. In both experiments, sessions of passive viewing of neutral pictures were...
INTRODUCTION: Autism is a neurodevelopmental disorder characterised by impaired social interaction, deficits in communication and stereotyped behaviours with synaptic dysfunction suggested as the major causative factor. However, the molecular mechanisms of synapses impairment remain unclear. The most recent studies point to mTOR, a regulator of protein synthesis at spines, as a potential molecular...
INTRODUCTION: Cyclin-dependent kinase 5 (Cdk5) belongs to the family of serine/threonine kinases and plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, including Alzheimer’s disease (AD). Moreover, our recent study demonstrated the involvement of Cdk5 in regulating inflammatory processes in the...
INTRODUCTION: Emerging epidemiology data indicate that maternal immune activation (MIA) resulting from inflammatory stimuli such as bacterial infections during pregnancy may constitute a risk factor for multiple neurodevelopmental diseases including autism spectrum disorders (ASD). Genetic and environmental variation, inflammation during early development, and their interaction can influence synaptic...
INTRODUCTION: α‑Synuclein (ASN) accumulation and mitochondrial dysfunction are central to the pathogenesis of most forms of Parkinson’s disease (PD) and appear to intersect, but how the two are related to each other has remained elusive. Recent research emphasised the important role of purinergic signalling dysfunction in PD. While the significant role of purinergic P2 family receptors in mitochondrial...
BACKGROUND AND AIMS: Hyperphosphorylation of Tau is involved in the pathomechanism of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Epidemiological data suggest the significance of early life exposure to lead (Pb) in etiology of disorders affecting brain function. However, the precise mechanisms by which Pb exerts neurotoxic effects are not fully elucidated. In this study,...
BACKGROUND AND AIMS: Autism spectrum disorders (ASD) are neurodevelopmental diseases impairing social behaviour and cognition. Shank proteins that are involved in the maturation and maintenance of synaptic function have been implicated in the pathogenesis of ASD. Prenatal maternal immune activation (MIA) is a risk factor for ASD and is commonly used as animal model of ASD. METHODS: We investigated...
BACKGROUND AND AIMS: The prominent features of Alzheimer’s disease (AD) are accumulation of amyloid beta (Aβ) oligomers and neuroinflammatory processes. Previous data demonstrated that activation of cyclin-dependent kinase 5 (Cdk5) may be essential for pathology of AD and other neurodegenerative disorders. In this study we focused on the role of Cdk5 in controlling gene expression in the brain in...
BACKGROUND AND AIMS: The purinergic P2 receptors for adenosine 5’-triphosphate (ATP) have been shown to be involved in neurodegenerative disorders including Parkinson’s (PD) and Alzheimer’s diseases (AD). However, the mechanisms underlying the disturbances in ATP-mediated neurotransmission is not clear. Our previous studies support the idea that α-Synuclein (ASN) oligomerisation and its intercellular...
BACKGROUND AND AIMS: It has been hypothesized that Se depletion followed by decreased activity of Se-dependent enzymes may be responsible for the development of oxidative stress observed in various neurodegenerative diseases. Thus, Se-dependent protection strategy to reduce neuronal oxidative injuries, can contribute to attenuation of neurodegeneration. The compound Selol is an organic mixture of...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.