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Dynamic bead-based microarrays offer an ideal platform for chemical and biological applications, including on-site chemical analysis, point-of-care medical diagnostics and synthetic biology on a chip. Despite significant development of dynamic microarrays, challenges have remained for achieving multi-stage fluidic reactions and analyses. Here we present a novel bead-based microarray platform - Microfluidic...
Subjects of this study are 12 persons divided into two even groups by the difference of involvement degree of playing video games. The subjects' brain waves of frontal lobe, parietal lobe, occipital lobe and temporal lobe are examined to find out how the subjects are affected after one hour of playing video games. The results show that α-waves and β-waves of the four lobes have no significant change...
This paper reports the first demonstration of single nucleotide polymorphism (SNP) genotyping via molecular beacon probes immobilized on polystyrene microbead substrates within a dynamic microfluidic system. Additionally, we present an optimized bead immobilization technique, micropost array trapping (muPAT), for high-density and high-throughput arraying of beads. Quantitative detection was achieved...
Prediction of transcription factor binding sites is a crucial challenge in investigation of mechanisms of gene expression regulation. Due to high diversity of different types of transcription factors and their DNA binding preferences, it is difficult to establish an accurate model for recognition of functional regulatory elements in promoters of eukaryotic genes. Here we present a tool for precise...
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