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INTRODUCTION: Perineuronal nets (PNNs) are brain extracellular matrix (ECM) formations enveloping selected neurons. They stabilize synaptic connections, thus limiting plasticity. Decrease in PNNs densities was observed after stroke and may be considered an attempt to create favorable conditions for neuroplasticity. PNNs are composed mainly of sugar moieties, therefore we hypothesize the role of polysaccharide...
BACKGROUND AND AIMS: Perineuronal nets (PNNs) are complex structures of the nervous system extracellular matrix, composed of hyaluronic acid and chondroitin sulfate proteoglycans. PNNs surround mostly the subset of parvalbumin-expressing interneurons by enwrapping their cell body and proximal dendrites. Their presence stabilizes existing synapses and limits neuronal plasticity. Mechanisms that regulate...