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Little is known about the relationship between neuronal gene expression and the architecture of the neuronal cell nucleus. We wanted to study the cell nuclei in neurons of the mouse cerebral cortex, using confocal microscopic immunocytochemistry. We used a segmentation algorithm, based on continuous boundary tracing, able to reconstruct the nucleus surface and to separate adjacent nuclei (Walczak...
PML is a tumor-suppresor protein involved in the pathogenesis of promyelocytic leukemia. In proliferating mammalian cells PML is a principal component of characteristic nuclear bodies, which contain other proteins but do not contain nucleic acids. There are several PML bodies per nucleus. The molecular function of PML protein is unclear, yet the majority of data points to its involvement in regulation...
Even though the molecular mechanisms of gene expression in neurons are quite broadly described in the literature, little is known about the relationship between these processes and the architecture of the neuronal cell nucleus. For example, it is firmly established that waves of gene expression occurring after neuronal stimulation comprise plenty of genes playing important roles in cognitive and epileptic...
Although the molecular mechanisms of gene-expression in neurons are comprehensively described in the literature, little is known about the relationship between these processes and the architecture of the neuronal cell nucleus. For example, it has never been examined whether bursts of transcriptional activity associated with seizures involve any regulation at the level of higher-order nuclear structure...