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INTRODUCTION: Schizophrenia is a devastating psychiatric disorder that impairs mental and social functioning and affects approximately 1% of the world’s population. It is known that in contrast to pharmacotherapy with typical antipsychotics, atypical antipsychotics alleviate not only the positive symptoms of schizophrenia but also the cognitive ones, however those effects are small and the mechanisms...
INTRODUCTION: A growing body of evidence implicates glutathione (GSH) deficiency and dysregulation of redox state in the pathophysiology of schizophrenia. AIM(S): The aim of the present study was to examine the effects of buthionine-S,R-sulfoximine (BSO)-mediated inhibition of glutamate cysteine ligase (GCL; an enzyme contributing to the GSH synthesis), during the early postnatal life on the GSH and...
BACKGROUND AND AIMS: The objective of the present study was to examine rotational behavior and monoamine metabolism in motor (striatum, STR; substantia nigra, SN) and limbic (prefrontal cortex, PFC; hippocampus, HIP) brain structures of unilaterally 6-OHDA-lesioned rats treated chronically with the chosen selective serotonin reuptake inhibitors (SSRIs): fluoxetine or paroxetine alone or jointly with...
BACKGROUND AND AIMS: Schizophrenia is a devastating psychiatric disorder that impairs mental and social functioning and affects approximately 1% of the world’s population. Although the atypical antipsychotics have some efficacy in alleviating social dysfunction in schizophrenic patients, this effect is small and mechanisms of this action are still unknown. Moreover, preclinical and clinical studies...
Several clinical reports have suggested a beneficial effect of the addition of a low dose of an atypical antipsychotic drug, e.g., olanzapine (OLA), risperidone (RIS) to the ongoing treatment with antidepressant drugs, particularly of the selective serotonin reuptake inhibitors (e.g., fluoxetine, fluvoxamine and paroxetine) in the treatment of drug-resistant depression. In anxiety disorders, like...
The effect of antidepressant drugs on tumour progress in animals models of stress is very poorly recognized. Further more a role of susceptibility to stress in modulatory effect of antidepressant drug on tumour growth have not been studied. The aim of present study was to establish the effect of individual reactivity to stress and prophylactic two weeks desipramine administration on metastatic colonization...
Tianeptine (TIA) is an antidepressant drug which enhances the reuptake of serotonin but, in contrast to tricyclics, shows no affinity for neurotransmitter receptors. The present study was aimed at determining whether repeated TIA treatment induced adaptive changes in the α 1 -adrenergic system, similar to those reported by us earlier for tricyclic antidepressants. The experiments were carried...
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