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INTRODUCTION: Inhibition of neuronal activity is shaped primarily by GABAA receptors. Agonist binding site (BS) at the β+/α‑ intersubunit interface is composed of 7 loops (A‑C from β and D‑G from α subunit), and the Loop G has been reported to play a major role in receptor activation, however the exact mechanism is not clear. α1F45 residue at Loop G has been shown to be engaged in receptor activation...
GABAA receptors mediate inhibitory transmission in the adult mammalian brain and are modulated by many clinically used drugs such as benzodiazepines. It has pre‑ viously been demonstrated that benzodiazepines affect binding and gating transitions. However, the mechanism of their modulation is still not fully understood. In our present study we address this problem by examining modulation of spontaneous...
BACKGROUND AND AIMS: The GABAA receptor is the main mediator responsible for inhibitory transmission in the brain. In our previous work (Szczot et al. 2014), we demonstrated for α1β2γ2 receptors that “classical” channel gating (opening/closing and desensitization) is preceded by a preactivation step, which is most likely initiated at the agonist-binding site. Here, we investigated the role of β2E155...
BACKGROUND AND AIMS: GABAA receptors (GABAAR) mediate the main component of ionotropic inhibitory transmission in adult mammalian brain. These receptors are heteropentamers and are strongly diversified throughout the CNS but the most frequent subunit composition is alpha1-beta2-gamma2. It has been reported that alpha1-gamma2 receptors can be potently expressed in recombinant GABAAR model (Verdoorn...
GABAA receptors are responsible for mediating inhibition in the adult mammalian CNS. These receptors are greatly diversified but the most common type is alpha1beta2gamma2. Intriguingly, GABA binding sites on GABAA receptor are remarkably distant (ca. 5 nm) from the channel gate. This structural feature raises the question about molecular mechanisms underlying the energy transfer from binding process...
Praca ta poświęcona jest zastosowaniu twierdzenia Banacha o punkcie stałym oraz pojęcia rozwiązań słabych do najprostszych problemów elektrotermii. Dla ośrodków elektrycznie i termicznie liniowych jednorodnych i izotropowych spoczywających w inercjalnym układzie odniesienia, sformułowane są w obszarze przestrzennym o gładkim brzegu i dla czasów z ograniczonego przedziału, przy użyciu kartezjańskich...
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