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INTRODUCTION: Over the last few decades, electromagnetic pollution from generated electromagnetic fields increases. Particularly important from the point of view of our health is the exposure to extremely low frequency electromagnetic fields (ELF‑EMF). ELF‑EMF is derived from many man-made sources, including power transmission lines or transformers. The effects induced by ELF-EMF exposure on biological...
INTRODUCTION: An electromagnetic field is a factor that people are exposed to constantly, from various sources. Thus, the interest in its influence on living organisms increases. AIM(S): The aim of this work was to investigate the long‑term effects of an extremely low frequency electromagnetic field 50 Hz (ELF-EMF) on stress-related behaviour. METHOD(S): Adult male Wistar rats were exposed to ELF‑EMF...
INTRODUCTION: The neuronal cell death associated with perinatal anoxia plays a significant role in neonatal morbidity and neurodevelopmental disability. In response to mild stress, a number of compensatory mechanisms are activated, which allows the cells to survive. Beside decreased body temperature, brain-derived neurotrophic factor (BDNF) is also considered to be beneficial to neuronal survival...
INTRODUCTION: Complications after neonatal asphyxia are the most common cause of subsequent neurological disorders. Transcriptional hypoxia‑inducible factor‑1α (HIF‑1α) plays the fundamental role in adaptive processes in response to hypoxia. Moreover, the most crucial role in neuronal plasticity is attributed to brain-derived neurotrophic factor (BDNF). Newborn mammals showing reduced physiological...
BACKGROUND AND AIMS: In asphyxiated newborns iron, deposited in the brain, contributes to formation of reactive oxygen species. METHODS: In our study we found an increased iron accumulation in neurons of rats exposed to neonatal anoxia under hyperthermic conditions which was prevented with deferoxamine (DFO) injection. Key factors in the cellular protection against oxidative stress are glutathione...
BACKGROUND AND AIMS: Complications after neonatal asphyxia are the most common cause of subsequent neurological disorders. The mechanism involved in brain damage is closely associated with abnormal iron metabolism that is a cofactor of free-radical reactions. There is a number of evidence that one of the endogenous processes that protect the brain from damage due to perinatal hypoxia is decreasing...
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