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The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding assay. The DNA unwinding suggests DNA intercalation, which could explain the inhibition...
Three new cyclohexene oxides, zeylenone, grandiflorone and grandifloracin, were isolated from the stem and leaves of Uvaria grandiflora and their structures established on the basis of spectral data. Zeylenone was found to be a highly active nucleoside transport inhibitor.
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