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Purpose Deliquescence is the process by which a solid undergoes dissolution by sorbing moisture from its surroundings when a characteristic relative humidity, RH0, is reached. For mixtures of two or more deliquescent solids, RH0 will generally be lowered. The goal of this research was to investigate the effect of small amounts of impurities or degradants on RH0 for a model deliquescent pharmaceutical...
No Heading Purpose. Deliquescence is a first-order phase transformation from solid to solution and occurs at a specific relative humidity (RH) that is characteristic to the solid. The goal of this research was to investigate the reduction in critical relative humidity (RH0) in binary solid mixtures of deliquescent active pharmaceutical ingredients (APIs) and deliquescent excipients. Methods. The...
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