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Using a high throughput screen based on the interaction of the HIV-1 gp41 ectodomain with the virucidal protein cyanovirin-N (CV-N), we isolated two new peptides which inhibited the binding of CV-N to gp41 and which subsequently showed anti-HIV activity in a whole cell assay. A 5-kDa (contrajervin) and 10 kDa (treculavirin) peptide were isolated from Dorstenia contrajerva and Treculia obovoidea, respectively...
Two varieties Viguiera tucumanensis, collected in two different geographical regions of Argentina, were shown to have a very close chemical constitution. They all gave the new diterpene clerod-14-ene-3α,4β,13ξ-triol. The taxonomic implications are discussed briefly.
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