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Synaptic exocytosis requires efficient SNARE complex assembly that is precisely regulated by multiple regulatory proteins. Increasing evidence suggests that Munc18‐1 and Munc13‐1 protect SNARE complex assembly in a manner resistant to NSF and α‐SNAP. However, the protective mechanisms of Munc18‐1 and Munc13‐1 are not fully understood. Here, by analyzing two pathways of SNARE complex assembly (i.e...
As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin‐1 and SNAP‐25 into a nonfusogenic product that precludes synaptobrevin‐2 entry, raising the question how the assembly of the SNARE complex is achieved. Here, we have investigated new functions of tomosyn in SNARE complex formation and SNARE‐mediated vesicle fusion. Assisted by NSF/α‐SNAP,...
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