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Cycloviolacin O2 (CyO2), a cyclotide from Viola odorata (Violaceae) has antitumor effects and causes cell death by membrane permeabilization. In the breast cancer line, MCF‐7 and its drug resistant subline MCF‐7/ADR, the cytotoxic effects of CyO2 (0.2–10 μM) were monitored in the presence and absence of doxorubicin (0.1–5 μM) using cell proliferation assays to establish its chemosensitizing abilities...
Folding of cofactor-binding proteins involves ligand binding in addition to polypeptide folding. We here assess the kinetic folding/binding landscape for Desulfovibrio desulfuricans flavodoxin that coordinates an FMN cofactor. The apo-form folds in a two-step process involving a burst-phase intermediate. Studies on Tyr98Ala and Trp60Ala variants reveal that these aromatics—that stack with the FMN...
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