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This work presents a generally-applicable technique for reconstructing transcription factor profiles from fluorescence microscopy images of GFP reporter systems. The approach integrates dynamic optimization and a Tikhonov regularization to avoid over-fitting caused by the highly ill-conditioned structure of this inverse problem. The advantage that the presented approach has over existing methods is...
The availability and quality of experimental data pose challenges for identifying the role of individual proteins in signal transduction pathways. To address this issue, this paper formulates and solves an inverse problem to determine the dynamics of transcription factors, i.e., one important class of proteins, from fluorescence intensity measurements of green fluorescent protein (GFP) reporter systems...
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