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Inositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts, metabolically stable analogs have been developed. Here,...
Diphosphoinositol‐5‐pentakisphosphate (5‐PP‐IP5), also known as inositol heptakisphosphate (5‐IP7), has been described as a high‐energy phosphate metabolite that participates in the regulation of multiple cellular processes through protein binding or serine pyrophosphorylation, a posttranslational modification involving a β‐phosphoryl transfer. In this study, utilizing an immobilized 5‐IP7 affinity...