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BackgroundIndividuals with type 2 diabetes (T2D) are at greater risk of bone fractures than those without diabetes. Certain oral diabetic medications may further increase the risk of fracture. Dipeptidyl peptidase‐IV (DPP‐IV) inhibitors are incretin‐based therapies that are being increasingly used for the management of T2D. It has been hypothesized that these agents may reduce fracture risk in those...
Studies linking insulin-like growth factor-1 (IGF-1) to age-related bone loss in humans have been reported but remain only correlative. In this investigation, we characterized the bone phenotype of aged WT C57BL/6J male mice in comparison to that of C57BL/6J mice with reduced serum IGF-1 levels arising from an igfals gene deletion (ALS knockout (ALSKO)). During the aging process, WT mice showed an...
Although the literature suggests a protective (anabolic) effect of insulin‐like growth factor‐1 (IGF‐1) on the musculoskeletal system during growth and aging, there is evidence that reductions in IGF‐1 signaling are advantageous for promoting an increase in life span through reduction in oxidative stress‐induced tissue damage. To better understand this paradox, we utilized the hepatocyte‐specific...
We observed structure and form of adult anulus fibrous of lumbar intervertebral disc at fibrous layer level. Anulus fibrosus of lumbar interverbral disc was delaminated microsurgical technique. 8 testing points were taken in each layer and the angles between their fibers going and horizontal plane were measured. We got the results: Fiber going angle at each measurement point ceaselessly increased...
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