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BackgroundIndividuals with type 2 diabetes (T2D) are at greater risk of bone fractures than those without diabetes. Certain oral diabetic medications may further increase the risk of fracture. Dipeptidyl peptidase‐IV (DPP‐IV) inhibitors are incretin‐based therapies that are being increasingly used for the management of T2D. It has been hypothesized that these agents may reduce fracture risk in those...
Although the literature suggests a protective (anabolic) effect of insulin‐like growth factor‐1 (IGF‐1) on the musculoskeletal system during growth and aging, there is evidence that reductions in IGF‐1 signaling are advantageous for promoting an increase in life span through reduction in oxidative stress‐induced tissue damage. To better understand this paradox, we utilized the hepatocyte‐specific...
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