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We present an approach for synchronizing hyperthermia and thermal-responsive local drug release. The targeting probe has a magnetite nanocrystal (Fe 3 O 4 @PSMA) core and a polynucleotide shell that carries 5-fluorouracil (5-FU) and anti-human epidermal growth factor receptor 2 (anti-HER2) antibody for cancer cell-specific targeting. The targeting nanocrystals play as an important...
The development of fluorescent iron oxide nanomaterials is highly desired for multimodal molecular imaging. Instead of incorporating fluorescent dyes on the surface of iron oxides, a ligand‐assisted synthesis approach is developed to allow near‐infrared (NIR) fluorescence in Fe3O4 nanostructures. Using a trimesic acid (TMA)/citrate‐mediated synthesis, fabricated Fe3O4 nanostructures can generate a...
A novel nanoconjugate enabled synchronization of localized hyperthermia and drug release was presented. The hyperthermia was induced by the radiofrequency (RF) at 1.3MHz to trigger the release of 5-fluouracil (5-FU) anti-cancer drugs from magnetite nanocrystals core by breaking their hydrogen bond with the polynucleotide polymer carrier. The anti-Human Epidermal Growth Factor Receptor 2 (anti-HER2)...
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