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Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Previous studies have demonstrated that OCT is capable of accurately visualizing the pathological changes in the living kidney in vivo using the Munich-Wistar rat model. In this work, we establish, for the first...
The objective of this study is to investigate the feasibility of imaging colon cancers using multi-modal optical imaging system combining optical coherence tomography (OCT) and fluorescence molecular imaging (FMI). This system enables simultaneous imaging of tissue morphology and molecular information at high resolution (10-20 mum) over a 3-5 mm field-of-view. OCT reveals the microstructures of normal...
Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can provide non-invasive, cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Previous studies have demonstrated that OCT can non-invasively visualize the pathological changes in the living kidney in real-time using the Munich-Wistar rat model. In this work, we demonstrate, for the first...
We present the application of optical coherence tomography (OCT) for non-destructive imaging and quantitative characterization of the macroporous cyclic acetal hydrogel cell scaffolds. High-resolution OCT visualizes the microstructures of the tissue engineering scaffolds in three-dimension. The porosity, pore size, and the interconnectivity of the hydrogel scaffolds were characterized quantitatively...
We have developed a hybrid optical tomography system combing optical coherence tomography (OCT) and line-scanning fluorescence laminar optical tomography (FLOT). This system could be used for concurrent depth-resolved tissue-structural and molecular imaging.
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