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GABA B receptors (GABA B Rs) are considered promising drug targets for the treatment of mental health disorders. GABA B Rs are obligate heteromers of principal GABA B1 and GABA B2 subunits. GABA B Rs can additionally associate with auxiliary KCTD8, 12, 12b and 16 subunits, which also bind the G-protein and differentially regulate G-protein signaling...
Activation of K+ channels by the G protein βγ subunits is an important signaling mechanism of G-protein-coupled receptors. Typically, receptor-activated K+ currents desensitize in the sustained presence of agonists to avoid excessive effects on cellular activity. The auxiliary GABAB receptor subunit KCTD12 induces fast and pronounced desensitization of the K+ current response. Using proteomic and...
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