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IFIT3, alternatively known as Retinoic Acid Induced Gene G (RIG-G) or IFI60, is a member of the ISG56/IFIT1 gene family together with IFIT1, IFIT2, and IFIT5. All these gene products are defined by a single repeated structural motif, the tetratricopeptide repeat, which contains 34 amino acids and adopts a basic helix-turn-helix fold. Members of the ISG56/IFIT1 gene family have been found to play roles...
Interferon (IFN) inducible genes are critical for the initiation of an effective antiviral response and for the clearance of virus from infected cells. Several hundred genes have been shown to be upregulated in response to IFN stimulation, however, only a fraction of these genes have been characterized to date. Dengue virus is a member of the Flavivirus genus of viruses and is of significant concern...
Interferon inducible genes are critical for the initiation of an effective antiviral response and for the clearance of virus from infected cells. These proteins exert their influence on viral replication via a myriad of different mechanisms, potentially influencing every step in the pathogens replicative cycle. Interferon stimulated genes have also been shown to mediate a wide array of cellular processes,...
Autophagy is a stress-induced cellular recycling mechanism that occurs at a basal level in all eukaryotic cells. Type I interferons are cytokines that have the ability to induce antiviral, antiproliferative and immunomodulatory activities in cells. Recently, we found that treatment with IFN-alpha2c and IFN-beta induces autophagy in Daudi B cells, starting at 24h as indicated by an increase of autophagy...
Secretion of recombinant proteins is a common strategy for heterologous protein expression using the yeast Kluyveromyces lactis. However, a common problem is degradation of a target recombinant protein by secretory pathway aspartyl proteases. In this study, we identified five putative pfam00026 aspartyl proteases encoded by the K. lactis genome. A set of selectable marker‐free protease deletion mutants...
Radioimmunoassays based on reactivity between a monoclonal antibody (mAb) and human 125 I-interferon (IFN)-α2 are frequently exploited in interferon research. In general, epitopes of antibodies specific for human IFN-α2 are located on the two immunodominant structures formed in the N- and C-terminal domains, respectively. We found that labelling of IFN-α2 with Na 12 ...
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