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CC and CXC chemokines are distinct chemokine subfamilies. CC chemokines usually do not bind CXC‐chemokine receptors and vice versa. CCR5 and CXCR4 receptors are activated by CCL5 and CXCL12 chemokines, respectively, and are also used as HIV‐1 coreceptors. CCL5 contains one conserved binding site for a sulfated tyrosine residue, whereas CXCL12 is unique in having two additional sites for sulfated/nonsulfated...
The N‐terminal segment of CCR5 contains four tyrosine residues, sulphation of two of which is essential for high‐affinity binding to gp120. In the present study, the interactions of gp120YU2 with a 27‐residue N‐terminal CCR5 peptide sulphated at position Y10 and Y14, i.e. Nt‐CCR5, were studied using 13C‐edited‐HMQC methyl‐NOESY [1H(13C)‐1H], combined with transferred NOE NMR spectroscopy. A large...