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Recent evidence validates a forgotten 40-year-old hypothesis: the MHC-related Fc receptor for IgG (FcRn) protects albumin from intracellular catabolic degradation, as it does for IgG, accounting for the uniquely long half-lives of both molecules and explaining their direct concentration–catabolism relationships. Albumin and IgG bind to FcRn at low pH but not at physiological pH. These two ligands...
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