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BackgroundFanconi anemia (FA) patients are hypersensitive to DNA alkylating agents and require lower doses than non‐FA patients to minimize serious toxicity. The mechanism by which hypersensitivity occurs is thought to be due to the inability of these individuals to effectively repair drug‐induced interstrand DNA–DNA crosslinks. We recently developed a highly sensitive assay for cyclophosphamide specific...
A sensitive and specific assay aimed at measuring the oxidized nucleic acids, 8-oxoguanine (8-oxoGua), fapy-guanine (Fapy-Gua), 8-oxoguanosine (8-oxoGuo), 8-oxo-2′-deoxyguanosine (8-oxodG) has been developed by coupling reversed phase liquid chromatography (HPLC) with electrospray tandem mass spectrometry detection (MS/MS) and isotope dilution. The HPLC–MS/MS approach with multiple reaction monitoring...
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