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Items from 81 to 100 out of 17,180,908 results

article

Screening system for epidermal growth factor receptor mutation detection in cytology cell‐free DNA of cerebrospinal fluid based on assured sample quality

Akihiko Kawahara, Hideyuki Abe, Kazuya Murata, Hidenobu Ishii, more

Background The cobas^® epidermal growth factor receptor (EGFR) Mutation Test v2 designed for cell‐free DNA (cfDNA) is approved as a companion diagnostic for osimertinib therapy. The aim of this study was to evaluate the concordance of EGFR mutation detection between paired primary or recurrent samples, and cerebrospinal fluid (CSF) cytology samples of lung cancer patients. Methods In total, 26 lung...

article

Touch imprint cytology on endoscopic ultrasound fine‐needle biopsy provides comparable sample quality and diagnostic yield to standard endoscopic ultrasound fine‐needle aspiration specimens in the evaluation of solid pancreatic lesions

Stefano Francesco Crinò, Alberto Larghi, Laura Bernardoni, Alice Parisi, more

Cytopathology > 30 > 2 > 179 - 186

Objectives Endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) is the gold standard for the diagnosis of solid pancreatic lesions (SPLs). Cytological samples can also be obtained using touch imprint cytology (TIC) on EUS fine‐needle biopsy (FNB) specimens. We aimed to compare sample quality and diagnostic yield of EUS‐FNA‐standard cytology (EUS‐FNA‐SC) to that of EUS‐FNB‐TIC in a series...

article

Developmental regulation of lifelong dental experiences and beliefs in Guangzhou and Hong Kong

Michael I. MacEntee, Sabrina T. Wong, Iris Chi, Edward C. M. Lo, more

Gerodontology > 36 > 1 > 18 - 29

Aims The aim of this study was to explain through the life‐course and life‐span perspectives of developmental regulation theory the controls on dental experiences and beliefs throughout the lives of older people in Guangzhou and Hong Kong. Background Dental diseases and disabilities among older people are serious public health concerns in China. Methods A facilitator conducted eight focus groups,...

article

Considering social determinants and the life‐course in oral health research

Linda Slack‐Smith

Gerodontology > 36 > 1 > 1 - 1

article

The relationship between oral‐health‐related quality of life and general health in an elderly population: A cross‐sectional study

Cristiane da Mata, Patrick Finbar Allen, Gerald John McKenna, Martina Hayes, more

Gerodontology > 36 > 1 > 71 - 77

Objective To assess the oral‐health‐related quality of life (OHRQoL) in a cohort of Irish older patients and explore associations with overall health status. Background The impact of oral health conditions on older individuals’ quality of life may be influenced by patients’ general health status. Materials and Methods This paper reports a cross‐sectional study, which analysed baseline data from...

article

The role of galectin‐3 in heart failure and cardiovascular disease

Xiao Zhong, Xiaoqian Qian, Guangping Chen, Xiang Song

Clinical and Experimental Pharmacology and Physiology > 46 > 3 > 197 - 203

Galectin‐3, a β‐galactoside‐binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in patients with cardiovascular disease. Genetic or pharmacological inhibition of galectin‐3 slows down the progression of myocardial inflammation, reduces collagen production, attenuates cardiac remodelling, and ameliorates cardiac function. In this review,...

article

MiR‐101a ameliorates AngII‐mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF‐κB signalling in a mouse model of hypertension

Hong Ding, Ying Zhou, Haihua Huang

Clinical and Experimental Pharmacology and Physiology > 46 > 3 > 246 - 254

Hypertensive nephropathy, clinically characterized by progressive renal fibrosis and inflammation, is a severe complication of hypertension. The objectives of this study were to investigate the roles of miR‐101a in relieving angiotensin II (Ang II)‐mediated hypertensive nephropathy and uncover the possible underlying mechanisms. A hypertensive mouse model was established via continuous 28‐day AngII...

article

A prospective, randomized trial of intravenous hydroxocobalamin versus noradrenaline or saline for treatment of lipopolysaccharide‐induced hypotension in a swine model

Vikhyat S. Bebarta, Normalynn Garrett, Joseph K. Maddry, Allyson Arana, more

Clinical and Experimental Pharmacology and Physiology > 46 > 3 > 216 - 225

Early, non‐clinical studies support the use of hydroxocobalamin to treat sepsis‐induced hypotension, but there is no translational, large animal model. The objective of this study was to compare survival in a sepsis model where large swine had endotoxaemia induced with lipopolysaccharide (LPS) and were treated with intravenous hydroxocobalamin (HOC), noradrenaline (NA), or saline. Thirty swine (45–55 kg)...

article

Neuregulin‐1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension

Rui Adão, Pedro Mendes‐Ferreira, Carolina Maia‐Rocha, Diana Santos‐Ribeiro, more

Clinical and Experimental Pharmacology and Physiology > 46 > 3 > 255 - 265

We have previously shown that treatment with recombinant human neuregulin‐1 (rhNRG‐1) improves pulmonary arterial hypertension (PAH) in a monocrotaline (MCT)‐induced animal model, by decreasing pulmonary arterial remodelling and endothelial dysfunction, as well as by restoring right ventricular (RV) function. Additionally, rhNRG‐1 treatment showed direct myocardial anti‐remodelling effects in a model...

article

Access to CF₃‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction

Guifang Han, Li Xue, Lili Zhao, Tiaozhen Zhu, more

Advanced Synthesis & Catalysis > 361 > 4 > 678 - 682

An unexpected Ag(I)‐catalyzed cascade reaction between substituted indolyl‐ynone and Togni's reagent has been disclosed in which multiple processes occur including indole dearomatization, ring expansion, trifluoro‐methylation and dehydrogenation. This one‐pot reaction can be used to conveniently access diverse CF₃‐containing multisubstituted cyclopentaquinolinone scaffolds in moderate to good yields...

article

Silver‐Catalyzed Carbocyclization of Azide‐Tethered Alkynes: Expeditious Synthesis of Polysubstituted Quinolines

Han Su, Ming Bao, Jingjing Huang, Lihua Qiu, more

Advanced Synthesis & Catalysis > 361 > 4 > 826 - 831

A silver‐catalyzed carbocyclization of azide‐tethered alkynes has been developed for the synthesis of polysubstituted quinolines in good to high yields. Mechanistic studies indicate that this reaction is initiated by a silver‐catalyzed 6‐endo‐dig azide‐yne cyclization, followed by a formal R−X (X=Cl, Br, or I) insertion with external halide through a ylide intermediate. The salient features of this...

article

Palladium‐Catalyzed Benzofulvenation of o‐Arylanilines through C−H Bond Activation by Using Two Diarylacetylenes as an Implicit Benzofulvene

Selvam Raju, Huan‐Chang Hsiao, Selvakumar Thirupathi, Pei‐Ling Chen, more

Advanced Synthesis & Catalysis > 361 > 4 > 683 - 689

We report the first example of Pd(II)‐catalyzed highly step‐ and atom‐economical benzofulvenation through free amine‐directed ortho C−H bond activation of o‐arylanilines. This paper presents a novel, simple, and efficient approach for the synthesis of benzofulvene derivatives from o‐arylaniline substrates through C−H bond activation with two diarylacetylenes as an implicit benzofulvene unit. The reactivity...

article

Synthesis of 4‐(Iso)Quinolinyl‐3(2H)‐furanones from (Iso)Quinoline N‐oxides and 1,4‐Diyn‐3‐ones: A Comparison of Copper Catalysis and Metal‐free Reaction

Xuetong Li, Tao Wang, Zunting Zhang

Advanced Synthesis & Catalysis > 361 > 4 > 696 - 701

A facile synthesis of (iso)quinolinyl‐3(2H)‐furanones from (iso)quinoline N‐oxides and 1,4‐diyn‐3‐ones in the presence of copper catalyst or under metal‐free conditions was developed. The resulting (iso)quinolinyl‐3(2H)‐furanones could be easily converted to (iso)quinolinyl‐isoxazoles, pyrazoles and polycyclic (iso)quinoline derivatives. In addition, the success in one‐pot, metal‐free synthesis of...

article

Palladium‐Catalyzed Propargylic [n+2] Cycloaddition: An Efficient Strategy for Construction of Benzo‐Fused Medium‐Sized Heterocycles

Zhen‐Ting Liu, Xiang‐Ping Hu

Advanced Synthesis & Catalysis > 361 > 4 > 836 - 841

No Abstract

article

Assembling 2D MXenes into Highly Stable Pseudocapacitive Electrodes with High Power and Energy Densities

Armin VahidMohammadi, Mehrnaz Mojtabavi, Nuala Mai Caffrey, Meni Wanunu, more

Advanced Materials > 31 > 8 > n/a - n/a

Electrochemical capacitors (ECs) that store charge based on the pseudocapacitive mechanism combine high energy densities with high power densities and rate capabilities. 2D transition metal carbides (MXenes) have been recently introduced as high‐rate pseudocapacitive materials with ultrahigh areal and volumetric capacitances. So far, 20 different MXene compositions have been synthesized and many more...

article

A Photoresponsive Rutile TiO₂ Heterojunction with Enhanced Electron–Hole Separation for High‐Performance Hydrogen Evolution

Chaomin Gao, Tao Wei, Yanyan Zhang, Xiaohan Song, more

Advanced Materials > 31 > 8 > n/a - n/a

Rutile titanium dioxide (TiO₂) is a promising photocatalyst due to its high thermodynamic stability and few intragrain defects. However, it has not yet achieved photocatalytic activity comparable to that of anatase TiO₂ owing to its higher recombination rate of electron–hole pairs. To effectively separate the electron–hole pairs in rutile TiO₂, a facet heterojunction (FH) structure to prolong the...

article

High‐Performance Flexible Freestanding Anode with Hierarchical 3D Carbon‐Networks/Fe₇S₈/Graphene for Applicable Sodium‐Ion Batteries

Weihua Chen, Xixue Zhang, Liwei Mi, Chuntai Liu, more

Advanced Materials > 31 > 8 > n/a - n/a

Sodium‐ion batteries (SIBs) have gained tremendous interest for grid scale energy storage system and power energy batteries. However, the current researches of anode for SIBs still face the critical issues of low areal capacity, limited cycle life, and low initial coulombic efficiency for practical application perspective. To solve this issue, a kind of hierarchical 3D carbon‐networks/Fe₇S₈/graphene...

article

Nanoconfinement‐Induced Giant Electrocaloric Effect in Ferroelectric Polymer Nanowire Array Integrated with Aluminum Oxide Membrane to Exhibit Record Cooling Power Density

Guangzu Zhang, Lingxi Weng, Zhaoyao Hu, Yang Liu, more

Advanced Materials > 31 > 8 > n/a - n/a

The electrocaloric effect (ECE) offers a unique mechanism to realize environmentally friendly and highly efficient solid‐state cooling that completely differs from the conventional vapor‐compression refrigeration. Here a new class of hybrid films composed of ferroelectric polymer nanowire array and anodic aluminum oxide (AAO) membrane is reported, which displays pronounced ECE driven by relatively...

article

Antenatal diagnosis of isolated infracardiac infradiaphragmatic total anomalous venous connection – Pictorial essay and discussion

Usha Nandhini, Monique Atkinson, Mani Ram Krishna, Thushari Indika Alahakoon

Australasian Journal of Ultrasound in Medicine > 22 > 1 > 61 - 65

Introduction Antenatal diagnosis of isolated infracardiac total anomalous pulmonary venous connection (TAPVC) is rare. Making the diagnosis antenatally is critical as delayed management could result in neonatal deterioration and poor outcome after surgery. Method A multipara at 29 weeks of gestation was referred to our tertiary unit for ultrasound review. The fetal growth and biophysical profile...

article

Time to establish pillars in point‐of‐care ultrasound

Carolynne J. Cormack, Anthony M. Wald, Peter R. Coombs, Leah Kallos, more

Australasian Journal of Ultrasound in Medicine > 22 > 1 > 12 - 14

Point of care ultrasound (PoCUS) has evolved rapidly and is used by many medical specialties. We propose five essential pillars of PoCUS that are necessary framework for hospital‐based PoCUS training and credentialing programs. The pillars are: governance, infrastructure, administration, education and quality. It is time to establish these pillars to ensure the best practice in PoCUS use.

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Search results

Screening system for epidermal growth factor receptor mutation detection in cytology cell‐free DNA of cerebrospinal fluid based on assured sample quality

Touch imprint cytology on endoscopic ultrasound fine‐needle biopsy provides comparable sample quality and diagnostic yield to standard endoscopic ultrasound fine‐needle aspiration specimens in the evaluation of solid pancreatic lesions

Developmental regulation of lifelong dental experiences and beliefs in Guangzhou and Hong Kong

Considering social determinants and the life‐course in oral health research

The relationship between oral‐health‐related quality of life and general health in an elderly population: A cross‐sectional study

The role of galectin‐3 in heart failure and cardiovascular disease

MiR‐101a ameliorates AngII‐mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF‐κB signalling in a mouse model of hypertension

A prospective, randomized trial of intravenous hydroxocobalamin versus noradrenaline or saline for treatment of lipopolysaccharide‐induced hypotension in a swine model

Neuregulin‐1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension

Access to CF₃‐Containing Cyclopentaquinolinone Derivatives from Indolyl‐ynones via Silver‐Catalyzed One‐pot Reaction

Silver‐Catalyzed Carbocyclization of Azide‐Tethered Alkynes: Expeditious Synthesis of Polysubstituted Quinolines

Palladium‐Catalyzed Benzofulvenation of o‐Arylanilines through C−H Bond Activation by Using Two Diarylacetylenes as an Implicit Benzofulvene

Synthesis of 4‐(Iso)Quinolinyl‐3(2H)‐furanones from (Iso)Quinoline N‐oxides and 1,4‐Diyn‐3‐ones: A Comparison of Copper Catalysis and Metal‐free Reaction

Palladium‐Catalyzed Propargylic [n+2] Cycloaddition: An Efficient Strategy for Construction of Benzo‐Fused Medium‐Sized Heterocycles

Assembling 2D MXenes into Highly Stable Pseudocapacitive Electrodes with High Power and Energy Densities

A Photoresponsive Rutile TiO₂ Heterojunction with Enhanced Electron–Hole Separation for High‐Performance Hydrogen Evolution

High‐Performance Flexible Freestanding Anode with Hierarchical 3D Carbon‐Networks/Fe₇S₈/Graphene for Applicable Sodium‐Ion Batteries

Nanoconfinement‐Induced Giant Electrocaloric Effect in Ferroelectric Polymer Nanowire Array Integrated with Aluminum Oxide Membrane to Exhibit Record Cooling Power Density

Antenatal diagnosis of isolated infracardiac infradiaphragmatic total anomalous venous connection – Pictorial essay and discussion

Time to establish pillars in point‐of‐care ultrasound

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