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In this work, we have successfully developed an enzyme free glucose sensor with highly performed electrodes, which was decorated with surfactant assisted platinum nanoparticles (PtNPs) on rectangular shaped thin Au film electrode. The PtNPs have been used for their outstanding catalytic activity for the redox reaction of H2O2. Diblock copolymer surfactant template was used to deposit platinum nanoparticles...
We present a sensor platform associated to silicon-nanowire chemical field effect transistors (Si-nw-ChemFET). Innovations concern the use of networks of suspended silicon N+/P/N+ nanowires as conducting channel, the realization by thermal oxidation and Atomic-Layer Deposition (ALD) of a SiO2/Al2O3 gate insulator all-around the silicon nanowires, and their final integration into covered SU8-based...
Reducing sensing time is one major concern in clinical diagnostics. In the present work, a robust measurement system is developed aiming at the faster and easier signal acquisition of memristive biosensors. Sensing chips consisting of nanofabricated silicon wires exhibiting memristive electrical response and metallic extension electrodes allowing an integrated measurement procedure are designed and...
Cyborg insects provide a unique platform to implement autonomous robotics on a large scale. Compared to vertebrates, insect cyborgs can be deployed in swarms and at a significantly lower cost. In this paper, we propose a cyborg sensing platform that leverages the acute olfactory sensing capability of locusts (Schistocerca americana) for standoff detection of target chemicals. Contrary to cyborg sensing...
In this article the fabrication process and test results of an electrochemical glucose biosensor based on zinc oxide (ZnO) nanowires (NWs) synthesized on an interdigitated electrode (IDE) is reported. The ZnO thin films and ZnO NWs were prepared by sol-gel and hydrothermal methods, respectively. The ZnO NWs, possessing good electron transfer, have shown good performance in glucose detection especially...
Mammalian taste system can detect and distinguish various taste signals presented by different tastants using various kinds of taste bud cells. This study described a novel bioelectronic sensor in which taste bud cells were used as biotransducer for detecting bitter signals to investigate taste signal transduction. Using a light-addressable potentiometric sensor (LAPS) as sensing chip to monitor both...
In this work, we demonstrate the quantification of creatinine (Cre) in human urine by using a molecularly imprinted polymer sensors (MIP). For creatinine binding, a carboxylic polyvinyl chloride (PVC-COOH) layer was functionalized onto screen-printed gold electrodes (Au-SPE). Afterward, a solution of acrylamide and bisacrylamide is polymerized around Au-SPE/PVC-COOH/Cre. For control, a non-imprinted...
To go toward non-invasive melanoma analysis without the requirement of biopsy, in vitro and in vivo investigations have been performed with near-field microwave sensing techniques. Preliminary dielectric study has been carried out on different types of skin crushes: normal skin and skin with a subcutaneous B16 melanoma tumor. Extracted dielectric properties permits to clearly discriminate the two...
This paper presents a label-free and non-invasive plasmonic sensor based on electrical cell impedance detection at sub-THz. The plasmonic sensor implemented by split-ring resonator (SRR) with different topologies is investigated in standard 65-nm CMOS process: differential T-line loaded SRR; stacked TEM-mode SRR and stacked TM-mode SRR. It is shown that sensor array with SRR has high sensitivity to...
There is a critical need of a fast, specific and reliable assay for biological species. To address this need, long period fiber gratings (LPFG) among other fiber optic sensors can be used because of their high sensitivity to changes in surrounding medium. In this work we fabricated and used two over-etched LPFGs. One of them was covered with T4 Phage and the other was covered with MS2 phage that both...
Gallium nitride (GaN) is a promising semiconductor material with high electron mobility, larger sheet carrier concentration, and wide energy bandgap. Open-gate AlGaN/GaN high electron mobility transistors (HEMTs) are shown to be an effective method for detection polar liquids. In this work, the pH sensing response of an open-gate HEMT is investigated. The device exhibits a good linear pH detection...
We have developed “Cavitas sensors” into human cavitas sites of oral cavity for non-invasive monitoring of saliva glucose. A salivary biosensor based on the integration of working electrode with an enzyme membrane on a mouthguard was fabricated and demonstrated. This mouthguard biosensor was integrated with a glucose sensor and wireless measurement system. In the investigation of in-vitro characterization,...
In this contribution the results on the development of a novel measurement system for electrochemical biosensing are presented. It covers the most important work on innovative graphene-based nanocomposites used in preparation of biosensing electrodes, design of different electrode types and a specialized flow chamber, specialized hardware and software for two versions (mobile and laboratory) of the...
Bovine leukemia virus (BLV) causes significant economic losses for cattle production. We report on an indirect optical method for the BLV detection, based on ultraviolet and visible photoluminescence of zinc oxide (ZnO) nanoparticles. High sensitivity and wide dynamic range of the biosensor from 0.001mg/ml to 1mg/ml of leucosis antibody was shown. The created immune biosensor fully meets the requirements...
Graphene has been realized for its significant physico-chemical properties. The extraordinary surface area and high electronical conductivity of graphene makes it a potential candidate in the field of nanoelectronics and sensors. In this study, graphene has been conjugated with silicon and its different physical and chemical properties were evaluated. The total energy of the composite system came...
To lower the overall cost of an optical cavity biosensor, while still taking advantages of highly sensitive Fabry-Perot based optical cavity structures, we have proposed the use of two low cost, off-the-shelf laser diodes and employ a scaled differential calculation method instead of monitoring the intensity changes of a single laser diode. This paper describes three of the benefits of using the scaled...
This paper presents the sensitivity analysis of a staggered heterojunctions based surrounding gate (SRG) Tunnel FET (TFET) based biosensor, for the first time. The sensitivity of the biosensor has been measured using the conventional change in threshold voltage as well as in terms of ION/IOFF ratio also. The results obtained using TCAD simulation reveals that the proposed biosensor outperforms the...
In this paper, design consideration of a surface plasmon photonic crystal fiber (PCF) biosensor for Glucose monitoring is presented and analyzed. Based on a well-known large mode area (LMA) PCF, two different configurations have been studied to investigate the effect of the etching process. The numerical results show that the plasmonic D-shaped PCF after etching three rows of air holes can achieve...
Cyber-Physical System (CPS) applications in lower-extremity bony-fracture rehabilitation systems require real-time biophysical data. Emerging and interesting solutions are microwave approaches that provide good contrast between hard and soft tissues and between local anomalies inside tissues. Preliminarily some contacting non-invasive planar methods have been investigated in their feasibility of detecting...
Sensor based ECG signal acquisition methods are non-invasive method for diagnosing heart related diseases. A noise removal ECG signal provides certain details about the electrical activity of the heart. The main focus of this paper is to identify the suitable filtering method for ECG signal noise removal for physiological parameter measurement and monitoring using TCP/IP Protocol. Feature extraction...
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