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The re-establishment of bone-tendon junction (BTJ) tissues is involved in many trauma and reconstructive surgeries. A direct BTJ repair requires a long period of immobilization which may be associated with a postoperative weak knee. In this study, we investigated if low-intensity pulsed ultrasound treatment increases the material properties of healing tissues at bone-tendon junction (BTJ) after partial...
Computed tomography is not the most frequent radiologic imaging procedure, but is arguably the most important in terms of clinical impact. CT is used extensively for emergencies, cardiovascular, pulmonary, gastrointestinal, endocrine, neurological, orthopedic and other applications - often as the first and only imaging procedure needed for diagnosis. The chances are very high that a patient will have...
In this study, a real-time compression based ultrasound elasticity imaging prototype was developed and evaluated for liver radio-frequency ablation (RFA) assessment under ex vivo and in vivo conditions. The prototype was implemented on a commercial ultrasound system (iU22, Philips Healthcare) for an L12-5 linear transducer and a C5-1 curvilinear transducer. Under the ex vivo condition, two bovine...
Understanding the kinematics of the knee joint as it undergoes normal physical activities is an important goal of the orthopaedic research community. The limitations of previous approaches to capturing knee kinematics include the requirement for tantalum beads to be implanted prior to imaging and the use of biplanar X-ray imaging which is not commonly available in hospital imaging departments. A recently...
Summary form only given. The mechanical competence of a bone depends on its density, its geometry and its internal trabecular microarchitecture. The gold standard to determine bone competence is an experimental, mechanical test. Direct mechanical testing is a straight-forward procedure, but is limited by its destructiveness. For the clinician, the prediction of bone quality for individual patients...
Patient motion affects image quality in high-resolution peripheral quantitative computed-tomography (HR-pQCT) and the quantitative analysis of bone quality using morphological parameters. We propose a method to automatically quantify the amount of patient motion contained in an acquired sinogram based on the Helgason-Ludwig consistency conditions (HLCC). The relation between the motion measure and...
Extensive recent work has taken place on the construction of probabilistic atlases of anatomical organ. We propose a probabilistic atlas of ten major abdominal organs which retains structural variability by using a size-preserving affine registration, and normalizes the physical organ locations to an anatomical landmark. Restricting the degrees of freedom in the transformation, the bias from the reference...
The design of most ulnar head implants is currently not based on studies of anatomical variations. To enable prosthesis design based on anatomical features, a method is developed for the detection of the ulna surface that articulates with the radius head. The articulating surface is detected by combining partial articulating ulna surfaces detected in CT scans of different individuals in different...
We propose an algorithm to solve the problem of time-resolved cardiac computed tomography (CT). The goal of the algorithm is to reconstruct a snapshot of the moving heart at any time instant from CT projection data acquired over a single heart-cycle. The object is modeled by a spatio-temporal state-space model which requires a nonlinear version of the Kalman Filter to assimilate the sequentially acquired...
Ultrasound and computed tomography registration is a valuable tool for interventional imaging and navigation, but current methods are limited in reliability or usefulness, requiring large fields of view, large ultrasound penetration depth, distinct image features, or contours of the investigated organs. Computationally cheap, small-field-of-view registration proved elusive so far. We propose the use...
Background: Treatment of malignant tumors of the pelvis, especially in the periacetabular region continues to present one of the most challenging problems in oncological and orthopedic surgery. Even now, hindquarter amputation is still the only choice for some patients, but hindquarter amputation can cause much trouble in sitting, standing and in fitting the exoprosthesis of patients after amputation,...
Based on CT scanning pictures from a volunteer's knee joint, a three-dimensional finite element model of the health human knee joint was constructed including complete femur, tibia, fibular, patellar and the main cartilage and ligaments. The model was validated by comparing with experimental and numerical results obtained from other authors. The pressure distribution of contact surfaces of knee joint...
To develop a three-dimension finite element model of Chinese human neck for dynamic response. A 50th percentile adult human was chosen as a model, the 3-D FE model of C1-T1 was constructed by SCT scanning technology to get data of DICOM format, software Materialise mimics and Pro-E to achieve three-dimension reconstruction, software TrueGrid to mesh. The model was composed of cervical vertebrae, discs,...
The study is to develop a three-dimensional finite element model to study the disease related to lumbo-pelvic-femoral complex. The CT images from the first lumbar vertebra to the upper third of femurs of a 25-years-old healthy male were obtained. Triangle mesh model was generated using these images by Simpleware. Then the whole solid model were set up after repair and optimization in Geomagic. The...
Information with respect to the internal stresses/strains in the human leg during bone-setting is helpful to control the medical robots in HIT-robot assisted orthopedic surgery system (HIT-RAOS). While techniques to measure external pressure are well established, direct measurement of the internal stresses/strains is difficult. A three-dimensional (3D) finite element model of the human leg is developed...
Patient-specific, interactive surgical simulation has become a major research direction in the biomedical side of computer graphics. While performing deformation on patients' medical volume data provides a realistic venue to define the most suitable operative strategy, the current simulators rely heavily on human efforts for data preprocessing. Such manual procedures not only require special knowledge...
In this study, we used multi-detector computed tomographic (MDCT) images of human left ventricles at end-diastole and end-systole to perform quantitative analysis and comparison of heart motion in patients with anterior wall myocardial infarction and ischemic cardiomyopathy (ICM) versus those with global non-ischemic cardiomyopathy (NICM). MDCT ventricular images of 25 patients (13 with ICM) with...
Coronary artery disease (CAD) or atherosclerosis is a leading cause of death in industrialized nations. Such diseases are marked by development of chronic vascular inflammation in coronary arteries. Accurate assessment, characterization and localization of this inflammation through non-invasive methods is an important step towards the treatment of CAD. It has been shown that positron emission tomography...
Dental implantation to a certain extent changes the biomechanical environment, thereby leading to the surrounding supporting bone to remodel. Computational remodeling has been well established in lone bone community and a range of mathematical formulae have been available with acceptable accuracy and effectiveness. However, there has been limited information and remodeling data available for dental...
Hyaluronic acid (170 kDa)-based hydrogel was synthesized using acrylated hyaluronic acid. Matrix metalloproteinase (MMP) sensitive hyaluronic acid-based hydrogels were prepared by conjugation with two different peptides: cell adhesion peptides containing integrin binding domains (Arg-Gly-Asp: RGD) and a cross-linker with MMP degradable peptides to mimic the remodeling characteristics of natural extracellular...
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