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Aging in humans may be accompanied by alterations in several functional abilities. However, there is a great deal of individual variability in the functions that may be altered with age within and across aged people. One potential source of age-related behavioral variation may lie in a differential vulnerability of neurobiological systems to the aging process in particular individuals. Aged monkeys...
The nucleus basalis magnocellularis (NBM) is the major cholinergic projection to neocortex in the rat and plays a role in the modulation of cortical activity. Lesions of the NBM decrease thickness of lamina II–III of frontal cortex and decrease soma size of lamina II–III neurons. Additionally, aging produces changes in neuron size and numbers in the basal forebrain and frontal cortex of rats. We assessed...
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