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B-lines, defined as discrete laser-like vertical hyperechoic reverberation artefacts in lung ultrasounds, have been shown to correlate with extravascular lung water in symptomatic and asymptomatic adults and children on dialysis. Recent studies have shown this technique to be useful in children on dialysis. B-line detection in lung ultrasound in children is novel and challenging. This paper presents...
Plane-Wave imaging enables very high frame rates, up to several thousand frames per second. Unfortunately the lack of transmit focusing leads to reduced image quality, both in terms of resolution and contrast. Recently, numerous beamforming techniques have been proposed to compensate for this effect, but comparing the different methods is difficult due to the lack of appropriate tools. PICMUS, the...
VisR ultrasound is an acoustic radiation force (ARF)-based imaging method that fits induced displacements to a 1D mass-spring-damper (MSD) model to estimate the ratio of viscous to elastic moduli, τ, in viscoelastic materials. A source of error in VisR τ estimation is complex and interrelated 3D system inertia. We hypothesize that error due to system inertia may be reduced by minimizing the volumetric...
The ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced 3-D nonlinear ultrasound imaging was investigated in a clinical population. Patients (n = 236) identified with breast lesions on mammography were scanned using power Doppler imaging, contrast-enhanced 3D HI, and 3D SHI on a modified Logiq 9 scanner (GE Healthcare). Time-intensity curve...
Echocardiographic image sequences are frequently corrupted by quasi-static “clutter” artifacts superimposed on the dynamic myocardium. Blind Source Separation (BSS) aIgorithms are often used to suppress clutter while retaining underlying tissue. In this paper, the sparse nature of reverberant artifacts in the time frequency domain is exploited for suppression to achieve reduced computational complexity...
MEMS technology has never been used for a non-imaging wearable ultrasound application, where e.g. lateral resolution is a minor issue. We combine finite element modeling and thin-plate analytic modeling and some measurements on MEMS devices, to optimize the performance of four MEMS layouts for a wearable bladder monitor. An array of square diaphragms, clamped on two sides, appears to be most favorable.
We investigate the potential utility of Magneto-hydrodynamics to enhance the acoustic pressure of electrically induced plasma sparks. We compared the displacements of a mylar polyester film caused by plasma sparks in three different settings: Case 1: No magnetic field; Case 2: Magnetic field generating Lorentz force towards the film, and Case 3: Magnetic field generating Lorentz in direction away...
We are developing a capsule ultrasound (CUS) device - a pill with the capability to scan the gastrointestinal (GI) tract through ultrasound. In this paper, we discuss the design and fabrication of the main components of the CUS device including the CMUT array, front-end electronics, and the wireless transmitter. We demonstrate a successfully fabricated 128-element CMUT array with polydimethylsiloxane...
Electrical brain mapping typically suffers from poor spatial resolution due to the uncertain spread of electric field lines through the brain and skull. To overcome this limitation, we propose 4D acoustoelectric brain imaging (ABI) for mapping current densities at a spatial resolution confined to the ultra-sound (US) focal spot. Acoustoelectric (AE) imaging exploits an interaction between a pressure...
High Intensity Focused Ultrasound as a non-invasive treatment method has gaining its popularity in various clinical application. HIFU is usually used with navigation system with which to make pre-operative plan. Our group developed a US-guided HIFU system for breast cancer treatment. In order to precisely remove the tumor region and reduce the damage to the surrounding normal tissue to minimal level,...
Kolo Medical Inc. has developed a 10 MHz 1.5D array probe using CMUT technology. The probe has 192 × 3 elements and a bandwidth covering from 4 MHz to 17 MHz. The probe does not require any switches to control elevation aperture size by utilizing DC bias. With ultra-wide bandwidth and 1.5D array, the probe is a one-probe solution to replace two or three linear array probes in clinical applications.
Superheated phase-change nanodrops are particles comprised of a fluorocarbon (PFC) core and lipid monolayer coating that stably exist in the liquid state at temperatures beyond their boiling point. Currently, these nanodrops are being researched as cavitation nuclei for ultrasound-mediated biomedical applications. The nanodrops are either fabricated at room temperature in the liquid state using a...
The purpose of this paper was to demonstrate a noninvasive technique to measure elastic properties of human eyes using ultrasound surface wave elastography (USWE) technique. Twenty eyes of 10 healthy subjects (age 44–63; mean 51 years) were studied. A localized harmonic vibration for 0.1 second at 100 Hz was generated by using a spherically-tipped vibrator (3 mm diameter) placed on the closed eyelid...
A wide spectrum of methods is used to image brain activation in vivo, such as functional MRI (fMRI) or positron emission tomography. Both techniques have excellent depth penetration but do not provide good spatial nor temporal resolution. By contrast, ultrasound imaging achieves good spatiotemporal resolution in depth, but until now its poor sensitivity has limited its use to the imaging of major...
Based on the multi-scattering theory for the micro particles, sound speed of the TiO2 nano particle suspension with ultra-low concentration was estimated. Good agreement was found between the estimated results and the experimental ones. The sound speed of 5 MHz ultrasound was measured with high accuracy, decreasing by about 0.15 m/s as concentration of suspension was changed in the range from 0.002...
In clinical diagnosis of liver cancer or treatment using US image guided navigation often required correlation of suspicious region in US with the clinical findings on CT or MR images. We proposed a faster automated registration technique consists of two-steps registration framework which contains vessel structure-based coarse registration and gradient feature-based fine registration. Results were...
The goal of project detailed in this paper was to develop a pharmacokinetic compartmental model for describing the complex activity of targeted microbubble (MB) contrast agents used for molecular ultrasound (US) imaging. This imaging study used renal cell carcinoma (RCC)-bearing mice. Either VEGFRR2-targeted or control MBs were intravenously injected. Each animal was imaged before MB injection and...
Perfusion imaging with conventional Doppler ultrasound is difficult due to frame rate and tissue clutter limitations. Consequently, conventional methods are only sensitive to velocities above 5–10mm/s for typical clinical imaging frequencies. To overcome this limitation and simultaneously address the frame rate and tissue clutter problems, we propose a technique that uses plane wave sequencing and...
Ultrasound transducer convert sound pressure waves to electrical signals or vice versa. Ultrasound transducers are applicable in industrial measurements and biomedical imaging. The optimization of ultrasound transducers has traditionally been done through trial and error, somewhat guided by one-dimensional simulations. This can often be a very time consuming and expensive process; hence a more extensive...
The need for new measurement techniques able to assess the nanofiller dispersion is still receiving great consideration when nanocomposites are developed. This occurs since different routes to disperse nanostructures generate molecular changes in polymer matrices that promote complex polymer–polymer and polymer–nanofiller interactions, which make difficult a suitable estimation of the dispersion....
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