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In this paper, a micro-needle array combined with transdermal delivery, as well as the detection of micro-sensors intelligent transdermal insulin delivery systems was designed with characteristics of pain-free, smart, timing, positioning, quantitative drug delivery. Transdermal delivery of the requirements for the design of the transdermal delivery of the microneedle array structure, and UV-LIGA process...
Purposes: To study the adhesive and the in vitro release properties of a mixture gel film prepared with two kinds of natural polysaccharides-konjac glucomannan and xanthan gum. Methods: The optimal formula was investigated by the quadratic regression rotatable orthogonal design with adhesive force as the evaluated parameter. Its in vitro release behavior was studied by the in vitro accumulative released...
Fast dissolution nanofiber membranes were prepared using electrospinning process with Ferulic Acid (FA)--a traditional Chinese medicine as the active pharmaceutical ingredients and a pharmaceutical hydrophilic polymer--polyvinylpyrrolidone K30 as the filament-forming matrix. Field Emission Scanning Electronic Microscopy (FE-SEM), Differential Scanning Calorimetry (DSC), Attenuated Total Reflection...
Rosette nanotubes (RNTs) are novel, biomimetic, synthetic, self-assembled drug delivery agents. Because of base stacking and hydrophobic interactions, the RNT hollow-tube structure can be used for incorporating drugs. Another advantage of using RNTs is their ability to be injected and become solid at body temperatures for orthopedic applications without the use of any external stimuli (such as UV...
High drug loading (DL) carrier is an effective way to cure the cancerous cells. High drug loading is also one of the key issues in the drug delivery research, especially the colonic drug delivery system by oral administration. The times of drug intake could be remarkably reduced if high drug loading carriers are administered. At the same time, the related formulation materials could be effectively...
This paper described the polymeric nanocapsules, which are regarded both an example of nanotechnology structured drug carrier and a particularly interesting technical solution to drug delivery due to its high repeatability outside a scientific laboratory, simplicity and robustness.
Patients in intensive care units are often prescribed a combination of sedative and analgesic to manage anxiety and pain relief. Proper sedation management is crucial to patient recovery but few intensive care units routinely employ strategies that tailor drug delivery to ongoing patient needs. The Infuse-Rite has been developed to automate a protocol that eliminates the possibility of excessive sedation...
Tissue engineering of vascular grafts still presents several shortcomings. Aiming to vascular regeneration, we developed a biomimetic multilayered scaffold with a middle pivotal collagen lamina between two functionalized layers of poly-L-lactide by means of electrospinning technique, with oriented drug-delivery capacity for the differentiation of human mesenchymal stem cells seeded therein. Applying...
We have developed a novel automated drug delivery system for simultaneous control of systemic arterial pressure (AP), cardiac output (CO), and left atrial pressure (PLA) in acute heart failure. The circulatory equilibrium framework we established previously discloses that AP, CO, and PLA are determined by equilibrium of the mechanical properties of the circulation, i.e. pumping ability of the left...
We present a novel microfluidic device for transdermal delivery of small quantities of drugs in brief time pulses for neurobiological studies. The device consists of dispensing and delivery channels connected to drug and buffer lines, respectively, and coupled by a check valve. The planar check valve and the microchannels are within a single flow layer which allows for simple fabrication and easy...
We present the principle and in vivo experimental results of high sensitivity terahertz imaging technique which enables the target specific sensing of cancers and the molecular imaging of drug delivery.
Mesoporous silica nanotubes (SNTs) and amine-functionalized SNTs (MSNTs) have been successfully synthesized and subsequently functionalized with blue fluorescent CdS quantum dots. The comparative study for several kinds of nanotube materials for the storage of ibuprofen indicated that the drug loading amount in CdS-incorporated MSNTs (CdS-MSNTs) could reach up to 740 mg/g silica, similar to that in...
The development of a more precise targeted delivery system is critical for the advancement of cancer chemotherapy. In this study, we evaluated the effects of RGD-conjugated poly (lactic acid-co-lysine)-(Arginine-Glycine-Aspartic) nanoparticles (PLA -PLL-RGD NPs) on targeted drug delivery for BACP-37 breast cancer. PLA-PLL-RGD NPs were prepared by using the emulsion method. A subsequent MTT assay indicated...
We present the first implantable MEMS drug delivery device that includes an electrochemical bellows pump, refillable drug reservoir, and dual regulation valve. Multiple drug pump configurations were fabricated, assembled, and tested. Delivery of agents for cancer radiation reduction was demonstrated. In vivo chronic delivery of radiation sensitizing agents in the form of small interfering (siRNA)-gold...
This paper report on a novel nano-electro-mechanical systems (NEMS) technology - nanoscale coaxial soft smart system (nCS3) that enables radial displacements of a multi-layered coaxial hollow fiber (CHF) and controlled modulations of a nanofluidic flow patterns inside the CHF responding to changes in local environments. The nCS3 has a unique nanostructure that consists of a liquid core and multiple...
This paper presents a dissolvable-tipped, drug-reservoir integrated microneedle array for transdermal drug delivery. The hydrogel-based dissolvable tips are formed in a reusable polydimethylsiloxane (PDMS) mold, and then contact-transferred onto a microtube array with drug-surrogate pre-filled reservoirs incorporated into each microneedle. The microtube array is fabricated by a single photolithography...
Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle...
The inventory management of traditional Chinese medicines is an important part of GMP and GSP. For pharmaceutical trading enterprises (sales), after the drug delivery before selling, the drugs are mostly stored in the warehouse in order to ensure drug safety, effectiveness and quality control, which are the basic duties of pharmaceutical trading enterprises. How to ensure drug safety, effectiveness...
An in-vivo body network is an interconnection of implanted medical devices without a wired or wireless connection. In this paradigm, the body's own circulatory network is utilized as the channel. Instead of electrical or electromagnetic signals, inert nano particles are used as the signal carrier. A framework for in-vivo communication along with a computer based model is developed. Simulation results...
A biodegradable controlled drug release microstructure with an array of micro chambers is a new kind of controlled drug delivery system which is made by biodegradable polymer. For a certain desired drug release profile, it is necessary to optimize the structure of the polymer device. In this study, a new mathematical model for a biodegradable controlled drug delivery system is presented by using Cellular...
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