The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Selecting an appropriate treatment regimen for an HIV-infected patient is a significant problem. We previously developed a regimen selection system for the first-round HIV/AIDS treatment based on the fuzzy discrete event systems (FDES) theory where type-1 fuzzy sets are used to represent experts' consensus. In clinical practice, different experts may have their own distinct knowledge and expertise...
Effective treatment of chronic hepatitis B virus (HBV) patients aims to prevent progression of chronic hepatitis B to cirrhosis, hepatocellular carcinoma, and eventually death. The use of mathematical modelling to explain the anti-HBV infection therapy has made a significant contribution for understanding the dynamics of host cells, viruses, the immune system. Chinese herbs are playing important roles...
To construct a recombinant vaccine alpha-fetoprotein (AFP)-heat shock protein (HSP70) complex, and study its ability to induce specific cytotoxic T lymphocyte (CTL) response and its protective effect against AFP-producing tumor. A recombinant vaccine was constructed by conjugating mouse heat shock protein 70. By way of intracutaneous injection, mice were primed and boosted with recombinant vaccine...
Since 1996, the National Institutes of Health and other organizations have recommended offering Highly Active Antiretroviral Therapy (HAART) to all patients infected with HIV. Although HAART provides a powerful strategy for HIV treatment, it does not prevent completely the development of multi-drug resistant strains, and drug resistance is the primary reason for treatment failure. A better control...
With the advance of immunology, immunogene therapy is becoming a possible therapeutic alternative to advanced cancer. The aim of tumor immunogene therapy is to enhance the immune response to tumors. Evidence suggests that CD80 (B7-1) and Interferon-gamma (IFN-gamma) play important roles in antitumor immunity induced by T lymphocyte. To study the antitumor immune effects of lung carcinoma vaccine modified...
This article introduces the property of magnetic field distribution and application of TMS developed by BJUT. The TMS generates time-varying magnetic field to stimulate the particular area in human brain. To obtain the distribution of magnetic density, we carried out survey by utilizing a Gauss meter, from three aspects: the distribution of magnetic density in axial direction, in radial direction...
This study was designed to develop and evaluate a chitosan-collagen-soybean phosphatidylcholine (SPC) complex film impregnated with mitomycin C (MMC)-PLA- nanoparticles for treatment of hepatocellular carcinoma in mice. MMC-PLA-nanoparticles were prepared by a reverse micelle-solvent evaporation method. PLA-MMC-nanoparticles were dispersed throughout the film. SEM, ATR-FTIR were used to character...
Based on the clinical date of the lamivudine plus adevovir divipolix (combination therapy) for HBeAg-positive chronic hepatitis B patients and the HBV infection dynamic model proposed by Nowak et al., this paper sets up a mathematical model consisting of two differential equation systems that enable us to describe and understand the dynamics of host cells, virus and the immune system. Our model provide...
PingYu capsule was a novel compound botanical drug, being composed of the extracts from Radix et Rhizoma Ginseng, Fructus Jujubae and Radix et Rhizoma Glycyrrhizae, which were the classical herbal medicines in China. Depression is one of psychological and/or physiological disorders. In the recent decades, depression affected the people's health seriously. This study was designed to demonstrate the...
Pollution made cancer a major disease threatening people's health. In the search for new cancer drug treatments, natural products perform an essential role. Escin, a mixture of triterpene saponins extracted from Aesculus Wilsonii Rehd., was used to analyze the cell growth inhibitory effects and the induction of apoptosis in human cervical carcinoma Hela cancer cell line in vitro. The results of MTT...
This study investigates the impact of focused ultrasound (FOS)-induced blood-brain barrier (BBB) disruption delivery of doxorubicin (DOX) on the survival of rats with aggressive glioma. Results show a modest but significant increase in median survival time in rats treated with combined FUS+DOX, while neither DOX nor FOS has any significant impact on survival on its own. Moreover, a post-treatment...
The performance of AMCBR reactor was monitored at a HRT of 1.5 days and at a organic loading rate of 3.2 kgCOD/m3day. The removal efficiencies of antibiotics were 89%, 90%, 91% and 88% respectively, after 30 days of operation period. The COD removal efficiencies were 90%, 91%, 92% and 89%. The total methane production was 10.841 l/day, while the methane percentage of total gas were 56%, 60%, 70%,...
Chemotherapy is a well-established medical practice for treatment of various types of cancers. A chemotherapy programme is prepared by a specialist doctor. Preparation, scheduling and management of chemotherapy programmes, especially when many patients with competing requirements are involved, are complicated tasks. A chemotherapy programme involves a number of cycles, each cycle involving application...
One of the major obstacles in developing drugs for diabetes is the lack of in vitro models that can capture more features of the dynamic insulin secretion. Here, we engineered an insulin secretion model by cell-assembly technique which can assemble cells into designated places to form complex three-dimensional structures. Adipose-derived stromal cells were assembled and induced differentiation into...
Multiwell plates in combination with optical inspection equipment are standard tools for biological and biomedical applications e.g. cell-to-cell interaction studies for cancer treatment. Microtechnology based multiwell plates have the potential to monitor physiological cellular interactions at single cell level with a high throughput e.g. for immunotherapy of cancer or targeted drug delivery, where...
Warfarin is the most frequently prescribed oral anticoagulant and the second most common drug implicated in emergency room visits for adverse drug events. At present, the appropriate dose of warfarin is usually determined empirically on an individual basis by measuring patient response, which has up to 60-fold variation among individuals. It is now understood that patient demographics and genetic...
Traumatic arthritis is a frequent clinical problem in active patients, manifested as synovitis and capsulitis. Progression to osteoarthritis (OA) after a period of time is a common sequela. Hyaluronan (HA) has been reported to be effective in treating chronic disability of OA. However, its potential for preventing joint with articular fracture from OA change is still unclear. We evaluated the effect...
Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin...
"Patient safety" is an important issue for patient self-care and for hospital management. How to decrease the opportunity of medication errors for patient is one of the important works in improving patient safety. The research proposes a system framework for building up an interoperability infrastructure for medication prescriptions exchange cross among different hospitals and clinics by...
HIV (human immunodeficiency virus) infection is fatal because it directly damages human's immune system by infecting CD4+ T cells. Treatment for HIV infection is a complex process that involves interactions among the virus population, the immune system and antiretroviral drugs. However, it is difficult to treat HIV infection because the high mutation rate helps HIV to escape from drug attacks. Therefore,...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.