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Personalized medicine will depend on sophisticated tools, analyses, and molecular level data and clinical information to provide optimized treatment based on each patient's individual characteristics such as health history, current health or disease status, and biochemical and physiological makeup. We discuss an approach to integrate clinical trial simulations with an optimization method to produce...
This paper presents and analyzes the data requirements within the clinical trial design process with particular focus on the selection of patients who are eligible to participate in the specified clinical study. The latter comprises an extremely time-consuming process which requires considerable budget and effort, whereas the resulting recruited subjects determine both the success of the clinical...
Glucocorticoids are considered to be indispensable agents in the treatment of hematologic malignancies. A critical established glucocorticoid action is the apoptotic effect they exert on leukemic cells. However, little is known about the molecular response of malignant cells on glucocorticoid exposure. Even less is known about the cell proliferation dynamics governing leukemic cells under glucocorticoid...
This paper presents a mathematical model for a novel synthetic gene regulatory network. The aim of this circuit is to behave as a bistable switch for in vivo delivery of short hairpin RNA (shRNA) which can induce RNA interference (RNAi) of a target mRNA. Through the mathematical analysis performed here, it will be shown how the circuit can be controlled to induce sustained expression of a shRNA, with...
Electroporation is an elegant technique used for proliferation control in Cancer cells. This budding mode of therapy called electrochemotherapy uses electrical pulses and chemodrugs to trigger cell death in cancerous cells. The efficacy of this technique depends on a variety of factors including electric field intensity, pulse duration and the number of pulses. In this study, Human cervical (ME180),...
Electroporation is the technique of applying high intensity, short duration pulses for effective drug/gene delivery for cancer therapies when conventional treatments do not work and/or costly with serious side effects and for chemo-resistive patients. Typically micro and millisecond pulses have been used by several researchers. Use of nanosecond pulse is gaining momentum due to its various advantages...
This paper has studied the application technology of physical medicine in the treatment of female reproductive system inflammation, and introduced the principles and comprehensive utilization of physical medicine. It also discusses the attention notes of physiotherapy in female reproductive system inflammation. This paper focuses on the physiotherapys of vulvitis, bartholinitis, vaginitis and cervicitis,...
Illuminating the underlying mechanism of drug action at single-cell and single-molecule levels is of great significance for the personalized treatment of diseases. In this paper, with the use of the atomic force microscopy (AFM), the mechanical property of the lymphoma cells was quantitatively measured and the CD20-Rituximab binding force was measured on the surface of the lymphoma cells by linking...
Mental illness has always been target of debate and criticism by the society (modern or ancient). Several problems and challenges regarding Psychiatry, Telepsychiatry specifically are found in literature. The lack of information and the fear of the unknown have long been seen as a barrier for people with mental illness as well as all those involved in the process, such as family and the medical team...
Lamivudine (LVD) is one of the popular drugs to be used for anti-hepatitis B virus infection therapy. About 39% HBeAg-positive chronic hepatitis B (CHB) patients can achieve serum hepatitis B virus (HBV) DNAs below the low limit of test after one years' treatment. However the antiviral-resistance HBV mutation to LVD treatment is near 60% after three year's therapy. Combination treatment is one method...
This article presents a way of modeling patient response to a pharmacotherapy by means of dynamic models with quantized output. The proposed modeling technique is exemplified by treatment of Parkinson's disease with Duodopa ®, where the drug is continuously administered via duodenal infusion. Titration of Duodopa ® is currently performed manually by a nurse judging the patient's motor symptoms on...
Medication management process in a hospital includes all the work that is done concerning to a certain patient's medical treatment. According to international studies, the process is very prone to errors, which can cause adverse drug events and endanger the patient safety. In this paper, we will show how medication management process can be improved by a user-centric and computer-based automated dose-dispensing...
Infectious microorganisms represent the causes of many of the most common and dangerous diseases in our modern society. Two major problems exist when tackling the problem of infections: detection and treatment. Here we utilize two distinct nanotechnology platforms to combat these problems. First, we demonstrate a novel detection method for identifying Mycobacterium tuberculosis DNA using rolling circle...
Cancer treatment by chemotherapy involves multiple applications of toxic drugs over a period of time. Optimising the schedule of these treatments can improve the outcome for the patient. A schedule of treatment and its effect on the tumour can be simulated by a mathematical growth model. However, when used in conjunction with a black-box optimisation algorithm such as an Evolutionary Algorithm (EA)...
Pharmaceutical companies face twin pressures of improving the throughput of new products and responding to increased requirements by regulatory bodies for risk evaluation and mitigation both pre- and post-marketing. This paper gives a brief overview of flexible outcome models to improve the accuracy of these studies. The focus is on the discovery of niche populations in secondary analysis and monitoring...
In this paper, optimal drug schedule for patients in progressive cancer phase who take the drug through infusion pump is obtained. An objective of control is reducing tumor cell numbers effectively while minimizing total amount of drug regimen. This is done because of the known serious side effects and major damages resulting from chemotherapy. Chemotherapy brings about weakness of the patient's immune...
Hypothyroidism results from an insufficiency either in the production or/and in the action of the thyroid hormones. Most of the patients in hypothyroidism state must adopt hormonal replacement therapy for all their lives. An intelligent controller model for supplying therapeutic drugs to primary hypothyroidism patients, without the thyroid gland, is investigated in this work. Two multilayer perceptron...
Diabetes Mellitus prevalence is escalating in epidemic proportions on the global basis. This disease affects various body organs. Due to that reason, it should be treated effectively. Hyperglycemia, a condition of diabetes is treated via insulin pump, pens and injections while hypoglycemia is treated by only glucagon injections. Significantly, there are not any such pumps available in the market aimed...
AIM Vaccaria segetalis was reported anti-tumor action in vitro. In this study, the effect and mechanism of inhibiting tumor growth and improving the quality of life of Vaccaria segetalis on mouse inoculated H22 solid carcinoma were investigated. METHODS The solid carcinoma model of mouse was made by H22 cells subcutaneous injection and they were divided into four groups including model control group,...
OBJECTIVE: To observe the change of Astrocyte (Ast) and cytokines, during vascular dementia (VD) formation to explore the prevention and treatment VD mechanisms of Xiongma dropping pill (XMDP). METHODS: To permanent bilateral ligation of the common carotid artery (2-VO) to establish a VD model. The glial fibrillary acidic protein (GFAP) on the rats brain, and IL-1β, IL-6 and TNF-α were observed by...
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