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The importance of pre-clinical research of single photon emission computed tomography(SPECT) imaging is now widely recognized. For the demand of high resolution and high detection efficiency, SPECT has been developed in several ways and it is simultaneously making demand for high quality imaging. This paper introduces the newly proposed dual-head L-SPECT system and investigates the initial performance...
Continuous scintillator crystals can offer several advantages over pixellated crystals. Apart from an increase of the active volume, spatial resolution is not limited to the crystal size and Depth of interaction (DoI) can be estimated from the light distribution. Continuous crystals coupled to finely segmented photodetectors can improve simultaneously spatial resolution and sensitivity, the main two...
We report the status of R&D on large triple-GEM detectors for a forward tracker (FT) in an experiment at a future Electron Ion Collider (EIC) that will improve our understanding of QCD. We have designed a detector prototype specifically targeted for the EIC-FT, which has a trapezoidal shape with 30.1° opening angle. We are investigating different detector assembly techniques and signal readout...
Dedicated brain PET scanner becomes an important tool for early diagnosis of Alzheimer's disease and brain function studies. The spatial resolution of the PET system can be improved by use of advanced depth-of-interaction (DOI) detectors, and its sensitivity can be enhanced by increasing its solid angle. Conventionally, PET scanners are designed based on a cylindrical geometry, and the sensitivity...
The existing SPECT system for nuclear cardiac imaging suffered from low sensitivity or high cost. In this study we implemented a novel design of the stationary dedicated cardiac SPECT combined with multi-pinhole collimators based on the clinical dual-head scanner with low cost. Previous simulation study has demonstrated the feasibility of the design. Accurate geometry calibration was implemented for...
We present an efficient readout scheme to acquire the outputs from two tiled SiPM detectors forming an 8×4 matrix of pixels capable of efficiently encoding event position, and that has good energy and time resolution, as well as depth of interaction capabilities. The characterization has been done using a 32×32 matrix of 1.3×1.3×12 mm3 LYSO crystals and a GSO/BGO phoswich illuminated with a 22Na source...
The aim of this work is to calculate the spatial resolution of an indirect converting flat panel detector using a computer simulation model based on the Monte Carlo method. The resolution is quantified by the Modulated Transfer Function (MTF). To calculate the MTF we used the edge image procedure and the slit image methodology. From those images, the MTF can be calculated through Fourier transformation...
Pixelated direct-conversion detectors are poised to replace scintillators in single photon emission computed tomography (SPECT) cameras with pixel-matching parallel-hole collimators, to compensate for lost resolution while yielding higher sensitivity. However, smaller pixel sizes to improve resolution leads to increased inter-crystal signal sharing, resulting in a drop in sensitivity. It is, therefore,...
Integrated PET/MRI enables simultaneous measurement of molecular, functional and anatomical information of the body in one combined scan, providing physicians and researchers with multi-parameter information. However, the long-term impact of integrated PET/MRI is limited by the high cost of the current commercial systems, which require the users to purchase both PET and MR subsystems, which are permanently...
The recently commissioned Energy-Resolved Neutron Imaging System, RADEN, located at the J-PARC Materials and Life Science Experimental Facility (MLF), is the world's first dedicated high-intensity, pulsed neutron imaging instrument. In addition to conventional radiography and tomography, the wide bandwidth and accurate measurement of neutron energy by time-of-flight is utilized to perform energy-resolved...
iQID (intensified quantum imaging detector) is a novel CCD/CMOS-based ultra-high-resolution photon-counting gamma-ray and x-ray detector technology recently developed at the Center for Gamma-Ray Imaging (CGRI) at the University of Arizona. In this work, we report further advances in iQID's capabilities in terms of dark-noise suppression, sensitivity and field of view (FOV). A new frame-parsing algorithm...
There is a strong potential demand for high-sensitivity and low-cost brain positron emission tomography (PET) imaging that is applicable to early diagnosis of Alzheimer's disease. Therefore, we have proposed a high-sensitivity dedicated brain PET geometry composed of a helmet detector having a hemisphere shape and a chin detector, which we call helmet-chin PET. Because the shape of a human head is...
This study investigates the effect of energy threshold on being able to include and position multiple-interaction photon events (MIPEs) detected in a cadmium zinc telluride (CZT) based small animal PET system we have built. Due to noise fluctuations, each channel's data acquisition trigger threshold should be adjusted above the noise floor, which limits the detection of photon interactions with energy...
The point-spread-functions (PSFs) of reconstructed images can be deformed due to the detector properties, such as the resolution and depth-of-interaction effects, and data geometries, such as the limited angular coverage in dual-panel PET systems. The PSF deformations cause decreased quantitative accuracy and consistency of the uptake measurements across the field of view. While reconstruction models...
Proton computed tomography (pCT) has the potential to improve the accuracy for proton therapy treatment planning. It will also be useful for pretreatment verification of patient positioning relative to the proton beam. The current approach to pCT requires that individual protons are tracked one by one. This requirement implies the development of fast detectors able to sustain a mean data rate of about...
‘Open-field’ PET imaging offers the key capability of correlating functional changes in the brain of an awake animal with its behavioral response to environmental or pharmacologic challenges. Previously we have demonstrated the feasibility of this concept for rats using motion compensation techniques. That system, however, is not suitable for imaging the mouse brain due to limitations imposed by the...
A three layer Compton telescope for dose monitoring in hadron therapy has been developed at IFIC. It consists of three detector layers and each layer is made of a continuous LaBr3 crystal coupled to four silicon photomultiplier (SiPMs) arrays. A dedicated image reconstruction method has also been developed. The telescope has been characterized and tested with radioactive sources and in-beam. Simulations...
Small-diameter muon drift tube (sMDT) chambers are a cost-effective technology for high-precision muon tracking. The rate capability of the sMDT chambers has been extensively tested at the Gamma Irradiation Facility at CERN in view of expected rates at future high-energy hadron colliders. Results show that it fulfills the requirements over most of the acceptance of muon detectors. The optimization...
We are developing brain SPECT system with excellent spatial resolution less than 5 mm like PET system. In this study we developed a full-digital gamma camera with position-sensitive photomultiplier tube (PMT) to achieve high spatial resolution and constructed SPECT system using it. In addition, we evaluated the performance of the developed gamma camera and SPECT system.
This paper documents the R&D undertaken jointly by the ISIS Neutron Detector Group and the Oxford University PImMS collaboration. The aim of this project was to develop a high resolution, energy resolved, neutron imaging detector named GP2. This conference record introduces the GP2 detector and lists its key physical properties; however the emphasis here will be on the earlier proof-of-principle...
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