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Breath analysis is becoming an attractive technique for the noninvasive monitoring of various molecular constituents in exhaled breath. Nitric oxide (NO) is a widely studied biomarker in breath and is known to indicate the lower airway inflammation associated with asthma. A mid-IR laser-based spectroscopic sensor and associated electronics were designed to measure exhaled NO simultaneously with CO...
Central (large airway) and peripheral (small airway) dysfunction frequently occur in patients with asthma and chronic obstructive lung disease. Measurement of the respiratory impedance can assist with diagnosis of pathological conditions. The forced oscillation technique (FOT) superimposes small pressure perturbations at the mouth during tidal breathing of a subject to measure lung mechanical parameters...
This paper introduces two new respiratory system models, the Mead-Cw model and the Mead-CI model, which are 6-component models that are intermediate in complexity between the well-known 7-component Mead model and the recently proposed 5-component augmented RIC model (derived from the Mead model by eliminating both Cw and Ct). Their modeling errors were compared to the RIC, extended RIC, augmented...
Obesity is a risk factor for asthma. The purpose of this study was to determine whether metformin, an agent used in the treatment of another obesity-related condition, type II diabetes, might have therapeutic potential for airway smooth muscle (ASM) function in obesity.
This paper describes the estimation of the parameter values for the recently introduced augmented RIC respiratory system model from Impulse Oscillometry data obtained from both asthmatic and normal children. An analysis of these values has indicated that one of the capacitance parameters of the model provides good discrimination between these two groups of children; moreover, this finding corresponds...
This paper describes the estimation of the parameter values for the recently introduced augmented RIC respiratory system model from impulse oscillometry data obtained from both asthmatic and normal children. An analysis of these values has indicated that one of the capacitance parameters of the model provides good discrimination between these two groups of children; moreover, this finding corresponds...
This paper describes the estimation of the parameter values for the recently introduced augmented RIC respiratory system model from impulse oscillometry data obtained from both asthmatic and normal children. An analysis of these values has indicated that one of the capacitance parameters of the model provides good discrimination between these two groups of children; moreover, this finding corresponds...
In this paper, we introduce a medical application of the Global Positioning System (GPS). For an asthmatic patient, he or she can carry a portable GPS device to prevent possible morbidity of asthma during his or her outdoor activities of daily livings. To reduce possible allergy asthma, the GPS-enable device continuously consults a remote server with sending user's position to decide whether current...
Impulse oscillometry (IOS) is an innovative patient-friendly pulmonary testing technique which measures the respiratory system impedance (Z) by using the spectral components of pressure to flow ratio which yields resistance and reactance values at different frequencies. The high dimensionality of IOS measurement data makes the analysis of this information difficult. Artificial neural networks (ANNs)...
Impulse oscillometry offers advantages over spirometry because it requires minimal patient cooperation, it yields pulmonary function data in a form that is readily amenable to engineering analysis. In particular, the data can be used to obtain parameter estimates for electric circuit-based models of the respiratory system, which in turn may assist the detection and diagnosis of various diseases/pathologies...
Respiratory sound analysis can offer important information related to pulmonary diseases. Wheezes have been reported as adventitious respiratory sounds in asthmatic or obstructive patients, during forced exhalation maneuvers. In this work, we propose a method for monitoring and analysis of respiratory sounds in frequency domain, during spontaneous ventilation. The database analyzed was acquired during...
In this paper we describe the application of a personal digital assistant (PDA) or pocket PC as an effective communication device to telemonitor levels of asthma triggering gases collected from a remote location under test to a workstation which has a personal computer (PC) running on Windows XPreg as the operating system. The Bluetoothreg features of the PDA are explored to transmit data collected...
Drug galvano-acupuncture is a new medical therapy that has been developed and refined over thirty-one years of research and clinical practice. It uses a combination of modern technology, traditional acupuncture, herbal medicine, and massage therapy techniques. The therapy works by inducing an electric field at the surface of the skin that allows various medications to penetrate the skin's surface...
The dynamic relationship between pressure and air flow at the mouth is usually described by the frequency dependence of the respiratory acoustical impedance (RAI). The RAI can be measured up to several hundred hertz by the use of forced excitation techniques. The RAI critically depends on the simplifications made in the characterization of the response of the respiratory system. In particular, the...
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