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In this study, we investigated the viscoelasticity of individual bone marrow-derived adult human mesenchymal stem cells (hMSCs), and the role of specific cytoskeletal component-F-actin microfilaments on the mechanical properties of individual hMSCs. The mechanical properties of hMSCs were determined using the micropipette aspiration technique coupled with a viscoelastic solid model of the cell. For...
The use of a collagen sponge as a three-dimensional lattice onto which fibroblastic cells are seeded for wound healing applications has been studied. Chick tendon fibroblasts were seeded onto a 2-cm/sup 2/ three-dimensional collagen matrix at 1.5*10/sup 6/ cells/cm/sup 2/ and cultured for 7 or 14 days. External loads of 0, 10 and 15 g were applied to this soft tissue composite. DNA and protein synthesis...
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