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Arterial geometry variability is present both within and across individuals. To analyze the influence of geometric parameters on maximal wall shear stress (MWSS) in the human carotid artery bifurcation, the computer simulations were run to generate the data pertaining to this phenomenon. In our work we evaluate various prediction models for modeling relationship between geometric parameters of the...
Breast cancer is the one of the most leading diseases and cause of death in the world. 21% of females diagnosed with breast cancer in 2009 did not survive. Hence, cancer therapy requires a new and novel approach to treat them. Over the last two decades, electroporation, which is the process by which external electrical pulses are applied to facilitate the transport of drugs into cells, is gaining...
The paper presents a foot pressure measuring system connected with EEG It can quantify the relationship between human gait cycle and EEG signals. Understanding the relationship will help in the prevention of potential motor dysfunction disease and the development of rehabilitation tools. The whole system is composed of three parts: EEG signal acquisition, foot landing signal acquisition and the synchronization...
There are certain oceanographic events specifically El Niño, tsunami, and hurricanes that catalyze and intensify disease breakouts. The ocean creates the prime environments necessary for bacteria to thrive or ocean-borne diseases to spread. In order to model phenomena like El Niño and take preventative measures against them, it is necessary to use probability distribution and numerical models as well...
Single Nucleotide Polymorphism (SNP) is the important part in genome wide association study (GWAS). We investigated the SNPs that are not genotyped directly or indirectly by the current GWAS, and genomic regions associated with these unassayed SNPs. Through analysis of Hap Map CEU (European Caucasian), CHB (Han Chinese), JPT (Japanese) and YRI (Yoruba African) data, we identified the NGS SNP-free...
Lots of studies have focused on the structure and function of high-quality human metabolic networks. Recently, hub-based centrality is used to analysis of human metabolic network core. However, it is clear that this specific centrality measure is not sufficient alone. In the present paper, by comparing 10 different centrality measures with their application to human metabolic network core, be similar...
Arbovirus constitutes a group of virus that is transmitted by arthropod's bites. Examples of diseases produced by this kind of virus are Dengue, Yellow Fever, and West Nile Virus, among others. These diseases are a major health problem in the world. In this work we formulate a system of differential equations to study the dynamics of an infection produced by arbovirus. For this, we consider the population...
The causation of cancer often involves the joint deregulation of multiple biological processes. Thus, it is interesting to extract multi-function features of cancer genes and study their functional coordination involved in tumorigenesis. Here, based on Gene Ontology, we proposed a heuristics strategy to extract multi-function features which are significantly overrepresented with cancer genes. We showed...
Diffusion tensor magnetic resonance imaging (DT-MRI) data should be preprocessed before they are used to analyses for searching white matter fiber structure of human brain. Fractional anisotropy (FA) calculated by DTI data has been widely used because it can describe the anisotropy prosperity of white matter. This paper presents some evaluation criterions to optimize the image preprocessing procedure...
The identification of disease microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. However, one major issue in microRNA studies is the lack of bioinformatics methods to accurately predict microRNA-disease associations. Herein, we proposed an approach to infer microRNA-disease...
Automatic location of acupuncture-point is an available way to the characterization of Chinese Medicine. In this paper, the content of infrared thermal image is investigated to mine the automatic location of facial acupuncture-point by the image processing technology. Since user's work is not involved in the location of acupuncture-point, the characterization of facial diagnosis can be greatly improved,...
The sensitive detection of molecular biomarkers in clinical samples is crucially important in disease diagnosis. In this study, we propose and develop aptamer microarray platform combined with novel sol-gel technology to identify low abundance targets from complex solution, such as serum. Due to nanoporous structure of sol-gel, it entraps a large number of active aptamers and allows aptamers to bind...
Prion protein (PrP) is probably the only known infectious protein that possesses chameleon-like features, as reflected not only in its conformation but also in its function. Cellular PrP (PrPC), rich in α-helical structures, is believed to be functionally involved in neurotransmitter metabolism, immune cell activation, cell adhesion, signal transduction, copper metabolism, antioxidant activity, and...
As the world's elderly population significantly increases, researchers are searching for ways to slow and prevent age-related diseases such as dementia. Currently, a growing body of research supports the effectiveness of using non-pharmacological interventions to reduce the decline of or improve brain functioning in people suffering from dementia. However, implementing and sustaining such interventions...
Single nucleotide polymorphisms are the most plentiful genetic variations of human genome. Haplytype is a group of interrelated SNP allele loci, which are located at one chromosome or certain regions. It has been the important composition of human genetic research in recent years. In the research on complex disease, the analysis of haplotype composed by many SNP loci is superior to the analysis of...
Codon usage preference and the highly expressed genes have strong correlations occur in many organisms. Codon usage preference of viruses may evolve much similar with its infected host to increase the fitness. In this study we investigated differences in codon usage preferences among influenza A H1N1 viruses which infected avian, swine and human, and may cause major pandemic around world. The relative...
Detemir that a 14-C fatty acid chain is attached to position B29 of DesB30 human insulin is a soluble insulin analog developed to ensure appropriate basal insulin supply. PEGylation is one way to prolong the time of insulin action. In this study methyl polyethylene glycol succinimidyl propionate (mPEG-SPA )was used as substitutes for 14-C fatty acid to modify the DesB30 human insulin. We will show...
Since diseases might be related with each other, systematically assessing their relationships could provide us novel insight into their mechanisms. One of the most important methods to study diseases' relationships is to calculate their phenotype similarity scores based on the text and clinical synopsis parts of their records in the OMIM database. However, as demonstrated in this paper, the similarity...
We determined the nucleotide sequence of a portion of the duck enteritis virus (DEV) strain CHv which was suspected to be the UL10 gene(GenBank accession no EU195100.), encoding glycoprotein M(gM). The UL10 gene was cloned and sequenced, which was composed of 1230 nucleotides encoding 409 amino acids, with a predicted molecular mass of 45.752 kDa. We calculated the codon usage bias in the newly identified...
A discrete mathematical model with time delays for the transmission of malaria is established. The basic reproductive number R0 of the model is defined. Numerical simulations are given to show that the disease free equilibrium is stable when R0<;1 and the unique positive equilibrium is locally asymptotically stable when R0 > 1. The elasticity of the basic reproductive number with respect to...
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