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Comparative analysis of protein interaction networks plays a key role in the study of evolution and molecular etiology of diseases. A topology-based method is proposed in this paper to search biologically significant sub networks in protein interaction networks with relatively high accuracy. Different with other methods, the present method takes into account incorrectness and incompleteness of biological...
Nearly 40 hereditary disorders in humans result from an increase in the number of copies of simple DNA repeats in genomic DNA. DNA repeats expansion mutations are dynamic and ongoing within tissues and across generations, leading to disease. These DNA repeats seem to be predisposed to expansion because they have unusual structural features, such as hairpins, slipped-strand DNA, DNA unwinding elements,...
The authors describe an innovative simulation framework that combines daily commuting network data with a commonly used population-based transmission model to assess the impacts of various interventions on epidemic dynamics in Taiwan. Called the Multilayer Epidemic Dynamics Simulator (MEDSim), our proposed framework has four contact structures: within age group, between age groups, daily commute,...
Nuclear transfer technology has the most important value in the academic research, animal industry and the livestock production. In the present paper, the developmental status of mammals in nuclear transfer was reviewed. Also, the research region and huge research achievement were summarized. Furthermore, the application and prospect of nuclear transfer technology in relational areas are presented.
Complex dynamics of two physiological signals, heart rate and physical activity, are introduced. Both are characterized by robust and anomalous (long-range correlated, non-Gaussian and/or non-Poisson) statistics, which break down in cases of neuro-cardiologic diseases and clinical depression, respectively. These signals, easily obtained continuously in everyday life, may serve as the “benchmark” of...
As the prevalent of information technology, the urban management became more and more dependent on information. Subsequently, the wanton propagation of harmful information often cause very serious damage on normal urban order, and is becoming a critical problem faced by modern urban management. In order to gain insight in the harmful information propagation and hold back it effectively, an experiment...
The heart rate variability (HRV) index can be used as a reference for the accessory diagnostic of the cardiovascular disease and the non-invasive monitoring in the recovery process. The complexity estimation is an important parameter for depicting the information quantities of the time sequence signals. The Kolmogorov Complexity of the HRV indexes among 106 samples from the normal human, patients...
We present an implemented method for automated quantification of neuronal beading. Beading is the “morphological hallmark” of axonal injury and is present in many neurological disease conditions as well. In vitro models of injury result in beading which has previously been difficult to quantify, and therefore difficult to use as a measurement of the degree of axonal injury. The beading program was...
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