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An important task of aging research is to find genes that regulate lifespan. Wet-lab identification of aging genes is a tedious and labor-intensive activity. Developing an algorithm to predict aging genes for guiding wet-lab experiment should be greatly helpful. In this paper, we systematically analyzed topological features of proteins encoded by Mus musculus aging genes versus those encoded by non-aging...
Transforming growth factor-beta (TGF-e) is one of the important cell factors which cause the fibrous function, and connective tissue growth factor(CTGF) is considered to be the downstream factor of TGF-e, mediates fibrosis of TGF-e. TGF-e induces the expression of CTGF through multiple signal transduction pathways in promoting fibrosis. This article provides a brief summary of the research progress...
Five lactobacillus strains which were obtained from traditional fermented foods in western China, were examined for use as probiotics and for anticancer biological products. The cell walls and cytoplasm extracts from lactobacillus strains were tested for anti-proliferative activity and induction of apoptosis. The results showed the cell walls showed significant direct anticancer activity. 16S rRNA...
To Investigate the intervention of Trigonella foenum greacum.L Saponin(TFGs) on urotensin II-induced cultured rat cardiac fibroblasts(CFs) transdifferentiation and its related molecular mechanisms. Cultured CFs were randomly divided into control group, U II stimulation and TFGs intervention group. Control group without any stimulation train, U II stimulate groups with 12-48 hours, induce of U II at...
Objective: To investigate the effect of ER-a36 siRNA on the growth of ER-breast cancer cell. Methods: The inhibitive effects of ER-a36 siRNA with various concentration on ER negative breast cancer cell at 24 h and 48 h were determined with MTT, the changes in DNA quantity was detected by Annexin V-FITC/PI staining, the expression levels of ER-a36 and pro-caspase-3 by Western blot. Results: ER-a36...
The pituitary gonadotropin luteinizing hormone (LH) play important roles in regulating gonad function and are essential for normal reproductive function in mammals. In this paper, compared with homologous sequences from available mammals, they displayed a high degree of conservation. Our results provided an insight into the characteristics of LHß.
Bisphenol A (BPA) is an environmental pollutant to which humans are universally exposed, evident as low BPA concentrations present in biological samples in the majority of individuals in developed countries. Although BPA is widely detected in blood, the main source of human exposure is through ingestion, as BPA is broadly used in the plastic industry and therefore present in food containers. In this...
It has been reported that GRP78 is highly expressed in gastric cancer, and it is considered as a marker for cancer progression and chemo-responsiveness, as well as target for cancer therapy. However, its potential role in gastric cancer development and progression is still unclear. Here, we found that GRP78 is highly expressed in tumor specimens from gastric cancer patients, and its expression was...
R-spondin family factors, known as regulators of e-catenin signaling pathway, are conserved in vertebrate. They play roles in multiple processes during vertebrate development. Rspo1, a member of R-spondin family, regulates sex differentiation in both mammals (e.g. mouse) and reptiles (e.g. turtle). However, the role of Rspo1 in fish remains elusive. Our previous work showed the expression of Rspo1...
We developed a measure of cytoskeletal linearity in order to study the biological properties of normal and hyperphosphorylated Microtubule Associated Protein Tau (MAPT). The effect of site-specific tau phosphorylation on the microtubule network was examined and the stability of the actin cytoskeletal was evaluated to determine its state under the influence of P-tau. A custom ImageJ plugin using the...
The rapid expansion in the amount of biological data being generated worldwide is exceeding efforts to manage analysis of the data. Annotation can be specified as any piece of information associated with an amino acid sequence. Annotation is a process of relating additional information with a particular point in a piece of information. The present task is completely based on the biological database...
The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a functional group. It is assumed that the active site configuration of the target protein is known with position of the essential residues. In this paper the interaction...
Chemerin is a protein bearing chemotaxis and anti-inflammation functions. Truncation of C-terminal region of chemerin precursor, prochemerin, regulates its activity. A reliable structure may help us understand the mechanism of such regulation. We model the full length prochemerin with a mixed strategy, that the cystatin-fold domain near the N-terminus is based on homology modeling of a template of...
Human articular cartilage tissue has limit capacity to heal itself. Tissue engineering is one of the high potential treatment strategies. In this study, alginate and crosslinked gelatin was chosen to used as a three dimensional scaffold for regeneration of human articular chondrocyte. Preliminary studies in animal were done to observe for their ability of redifferentiation and chondrogenic property...
Myocardial infarction (MI) is a leading cause of deaths in the United States. Currently, the high mortality rate in MI is partially due to the lacking of diagnostic and prognostic biomarkers. Therefore, the purpose of this study was to develop a framework to understand MI-specific protein interaction network and identify MI-specific biomarkers with public databases and literatures. We established...
A typical method to discover phenotypic descriptions of an ordered set of differential gene expressions is to identify pathway enrichments. There are many pathways that are highly related or maybe redundant across different databases making their consolidation an essential step when interpreting these results. Two methods of pathway consolidation are explored, one utilizes the gene set of the most...
The recent success of genome-wide association (GWA) studies has greatly expanded our understanding of many complex diseases by delivering previously unknown loci and genes. A large number of GWAS datasets have already been made available, with more being generated. To explore the underlying moderate and weak signals, we recently developed a network-based dense module search (DMS) method for identification...
Avian Influenza Virus (AIV) has already crossed species barriers to infect humans, but the reason for avian flu cross-species infection is unknown. A lot of biology experiment accumulated tens of thousands of biological information data. As a new technology based on database and statistics, data mining provides unprecedented data analysis tool to biologists and powerful means to gene and protein's...
Signal transduction pathways control cellular responses to stimuli, but it is unclear how molecular information is processed as a network. Large-scale collection and systematization of such data is likely to have a great impact on cell biology as complete genome sequencing has had on genetics. Cell signaling pathways interact with one another to form networks. Such networks are complex in their organization...
Post-translational modifications (PTMs) of his tone proteins play critical roles in establishing functionally separated domains on chromatin and regulating important biological processes, such as transcription. These modifications often act in cooperative manner, forming complicated "histone codes". Elucidation of functional relationships among them will, therefore, significantly increase...
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