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Waschek, J. A., V. Lelievre, D. T. Bravo, T. Nguyen and J.-M. Muller. Retinoic acid regulation of the Vip and Pacap autocrine ligand and receptor system in human neuroblastoma cell lines. Peptides 18(6) 835–841, 1997.—Neuroendocrine tumors, neuroblastoma in particular, commonly express the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP)...
Hybrid polar compounds, of which hexamethylene bisacetamide (HMBA) is the prototype, have been shown to be potent inducers of differentiation of many types of transformed cells. With virus-transformed murine erythroleukemia cells as a model, HMBA was shown to cause these cells to arrest in G 1 phase and express globin genes. HMBA action involves modulation of factors regulating G 1 ...
The majority of cancer patients succumb to the consequences of metastatic disease. A correlation of increased nm23 expression to low metastatic potential has been established in several malignancies, based on published prognostic studies with tumour cohorts and transfection studies. Transfection of highly metastatic MDA-MB-435 human breast carcinoma cells with nm23-H1 cDNA resulted in a significant...
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