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A p53 network immunohistochemically‐based signature to discriminate between good and poor prognosis breast cancer would have clinical relevance, given the key role of p53 in malignancy and response to therapy. Utilizing a five‐protein signature of p53/mdm2/mdm4/bcl2/p21 discriminates good‐prognosis and poor‐prognosis patient groups, based on the functionality of the p53 network. However, the relationship...
Microtubule end‐binding protein 1 (EB1) is an evolutionarily conserved protein that regulates microtubule dynamics and participates in diverse cell activities. Here, we demonstrate that EB1 expression is up‐regulated in human breast cancer specimens and cell lines. The level of EB1 correlates with clinicopathological parameters indicating the malignancy of breast cancer, including higher histological...
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