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Radiation resistance in breast cancer resulting in residual lesions or recurrence is a significant cause to radiotherapy failure. Cancer‐associated fibroblasts (CAFs) and radiotherapy‐induced senescent CAFs can further lead to radiation resistance and tumor immunosuppressive microenvironment. Here, an engineering cancer‐cell‐biomimetic nanoplatform is constructed for dual‐targeted clearance of CAFs...
The β‐relaxation is one of the major dynamic behaviors in metallic glasses (MGs) and exhibits diverse features. Despite decades of efforts, the understanding of its structural origin and contribution to the overall dynamics of MG systems is still unclear. Here two palladium‐based Pd─Cu─P and Pd─Ni─P MGs are reported with distinct different β‐relaxation behaviors and reveal the structural origins for...
Engineering advanced functional materials such as Anatase crystals through the molecular tuning of crystal facets is the current enigma of interest pertinent to solving the structure‐property‐performance triad. Developing optimal shapes and sizes of crystallite necessitates exploring the nanoscopic growth mechanism via precursor tracking. Here, the tapestry of particles varying in dimensionality (0D–3D),...
Enantiomers (opposite chiral molecules) usually exhibit different effects when interacting with chiral agents, thus the identification and separation of enantiomers are of importance in pharmaceuticals and agrochemicals. Here an optical approach is proposed to enantioselective trapping of multiple pairs of enantiomers by a focused hybrid polarized beam. Numerical results indicate that such a focused...
Macrophage dysfunction is one of the primary factors leading to the delayed healing of diabetic wounds. Hypoxic bone marrow mesenchymal stem cells‐derived exosomes (hyBMSC‐Exos) have been shown to play an active role in regulating cellular function through the carried microRNAs. However, the administration of hyBMSC‐Exos alone in diabetic wounds usually brings little effect, because the exosomes are...
Mechanosensitive molecular junctions, where conductance is sensitive to an applied stress such as force or displacement, are a class of nanoelectromechanical systems unique for their ability to exploit quantum mechanical phenomena. Most studies so far relied on reconfiguration of the molecule‐electrode interface to impart mechanosensitivity, but this approach is limited and, generally, poorly reproducible...
Liposomes are widely used in the biological field due to their good biocompatibility and surface modification properties. With the development of biochemistry and material science, many liposome structures and their surface functional components have been modified and optimized one by one, pushing the liposome platform from traditional to functionalized and intelligent, which will better satisfy and...
III–VI metal chalcogenides have garnered considerable research attention as a novel group of layered van der Waals materials because of their exceptional physical properties and potential technological applications. Here, the epitaxial growth and stacking sequences of InTe is reported, an essential and intriguing material from III–VI metal chalcogenides. Aberration‐corrected scanning transmission...
The progression of self‐powered micro/‐nanomotors (MNMs) has rapidly evolved over the past few decades, showing applications in various fields such as nanotechnology, biomedical engineering, microfluidics, environmental science, and energy harvesting. Miniaturized MNMs transduce chemical/biochemical energies into mechanical motion for navigating through complex fluidic environments with directional...
Bispecific antibodies possess exceptional potential as therapeutic agents due to their capacity to bind to two different antigens simultaneously. However, challenges pertain to unsatisfactory stability, manufacturing complexity, and limited tumor penetration hinder their broad applicability. In this study, a versatile technology is presented for the rapid generation of bispecific nanobody‐aptamer...
To date, the excellent mass‐catalytic activities of Pt single‐atoms catalysts (Pt‐SACs) toward hydrogen evolution reaction (HER) are categorically confirmed; however, their high current density performance remains a challenge for practical applications. Here, a binder‐free approach is exemplified to fabricate self‐standing superhydrophilic‐superaerphobic Pt‐SACs cathodes by directly anchoring Pt‐SAs...
Developing efficient, robust, and cost‐effective trifunctional catalysts for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) at high current density and high temperature is crucial for water splitting at industry‐level conditions and ultra‐high‐temperature Zinc‐air battery (ZAB). Herein, cobalt nanoparticles well‐integrated with nitrogen‐doped...
T‐Nb2O5 characterized by the pronounced intercalation pseudocapacitance effect, is regarded as a promising and alternative anode for fast‐charging Li‐ion batteries. However, its electrochemical kinetics are still hindered by the absence of sufficient and homogenous conductive wiring inside active microparticles. Herein, an in situ pillaring strategy of electronic nano‐wires is proposed to slice T‐Nb...
In future information storage and processing, magnonics is one of the most promising candidates to replace traditional microelectronics. Yttrium iron garnet (YIG) films with perpendicular magnetic anisotropy (PMA) have aroused widespread interest in magnonics. Obtaining strong PMA in a thick YIG film with a small lattice mismatch (η) has been fascinating but challenging. Here, a novel strategy is...
High‐entropy alloys nanoparticles (HEAs NPs) have gained considerable attention due to their extensive compositional tunability and intriguing catalytic properties. However, the synthesis of highly dispersed ultrasmall HEAs NPs remains a formidable challenge due to their inherent thermodynamic instability. In this study, highly dispersed ultrasmall (ca. 2 nm) PtCuGaFeCo HEAs NPs are synthesized using...
Chimeric antigen receptor natural killer (CAR‐NK) cell therapy represents a potent approach to suppressing tumor growth because it has simultaneously inherited the specificity of CAR and the intrinsic generality of NK cells in recognizing cancer cells. However, its therapeutic potency against solid tumors is still restricted by insufficient tumor infiltration, immunosuppressive tumor microenvironments,...
Osteoarthritis (OA) is a typical joint degenerative disease that is prevalent worldwide and significantly affects the normal activities of patients. Traditional treatments using diclofenac (DCF) as an anti‐inflammatory drug by oral administration and transdermal delivery have many inherent deficiencies. In this study, a lubricating microneedles (MNs) system for the treatment of osteoarthritis with...
A crystalline porous bipyridine‐based Bpy‐COF with a high BET surface area (1864 m2 g−1) and uniform mesopore (4.0 nm) is successfully synthesized from 1,3,5‐tris‐(4’‐formyl‐biphenyl‐4‐yl)triazine and 5,5'‐diamino‐2,2'‐bipyridine via a solvothermal method. After Cu(I)‐loading, the resultant Cu(I)‐Bpy‐COF remained the ordered porous structure with evenly distributed Cu(I) ions at a single‐atom level...
The ligament, which connects bones at the joints, has both high water content and excellent mechanical properties in living organisms. However, it is still challenging to fabricate fibrous materials that possess high water content and ligament‐like mechanical characteristics simultaneously. Herein, the design and preparation of a ligament‐mimicking multicomponent fiber is reported through stepwise...
A simple, reliable method for identifying β‐lactoglobulin (β‐LG) in dairy products is needed to protect those with β‐LG allergies. A common, practical strategy for target detection is designing simplified nucleic acid nanodevices by integrating functional components. This work presents a label‐free modular β‐LG aptasensor consisting of an aptamer‐loop G‐quadruplex (G4), the working conformation of...