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BACKGROUND:Previous cost‐effectiveness analyses of tamoxifen therapy account for breast cancer risk reduction during active treatment but not for its persistent protective effect after active treatment.
METHODS:A detailed, continuous time, mathematical model of breast cancer and healthcare processes was used to simulate a postmenopausal population aged <55 years in a virtual trial comparing tamoxifen...
We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits growth of MCF‐7 and MDA‐MB‐231 human breast cancer cells in culture and MDA‐MB‐231 xenografts in vivo by causing apoptosis. However, the mechanism of WA‐induced apoptosis is not fully understood. The present study was designed to systematically determine the...
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