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ObjectiveTo compare manual and automated preoperative and postoperative hippocampal volume measurements in patients with intractable epilepsy.
MethodsWe studied 34 patients referred to the Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) for evaluation of intractable epilepsy and 21 normal volunteers who received 1.5 or...
PurposeLimbic encephalitis is an autoimmune‐mediated disease leading to temporal lobe epilepsy, mnestic deficits, and affective disturbances. Magnetic resonance imaging (MRI) usually shows signal and volume changes of the temporomesial structures. However, these abnormalities may be subtle, thereby hampering the diagnosis by conventional visual assessment. In the present study we evaluated the diagnostic...
Purpose: To describe a novel magnetic resonance imaging (MRI) postprocessing technique for the detection of periventricular nodular heterotopia (PNH) and to evaluate its diagnostic value. The method is a further development of voxel‐based morphometric analysis with focus on a region of interest around the lateral ventricles to increase the sensitivity and specificity for automated detection of abnormally...
Purpose: Mossy fiber sprouting (MFS) is a frequent finding following status epilepticus (SE). The present study aimed to test the feasibility of using manganese‐enhanced magnetic resonance imaging (MEMRI) to detect MFS in the chronic phase of the well‐established pilocarpine (Pilo) rat model of temporal lobe epilepsy (TLE).
Methods: To modulate MFS, cycloheximide (CHX), a protein synthesis inhibitor,...
Purpose: Patient studies have not provided consistent evidence for interictal neuronal hyperexcitability inside the seizure‐onset zone (SOZ). We hypothesized that gray matter (GM) loss could have important effects on neuronal firing, and quantifying these effects would reveal significant differences in neuronal firing inside versus outside the SOZ.
Methods: Magnetic resonance imaging (MRI) and computational...
Purpose: To validate the use of 18F‐fluorodeoxyglucose–positron emission tomography/magnetic resonance imaging (FDG‐PET/MRI) coregistration for epileptogenic zone detection in children with MRI nonlesional refractory epilepsy and to assess its ability to guide a second interpretation of the MRI studies.
Methods: Thirty‐one children with refractory epilepsy whose MRI results were nonlesional were...
Purpose: The aim of this study was to evaluate phospholipid metabolism in patients with malformations of cortical development (MCDs).
Methods: Thirty‐seven patients with MCDs and 31 control subjects were studied using three‐dimensional phosphorus magnetic resonance spectroscopy (31P‐MRS) at 3.0 T. The voxels in the lesions and in the frontoparietal cortex of the control subjects were compared (the...
Frontal lobe epilepsy (FLE) is considered the second most common type of the localization‐related epilepsies of childhood. Still, the etiology of FLE in children, its impact on cognitive functioning and behavior, as well as the response to antiepileptic drug treatment in children has not been sufficiently studied. This review focuses on these aspects of FLE in childhood, and reveals that FLE in childhood...
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