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Eight patients with difficult to control epilepsy and an active or a history of psychosis were treated with vigabatrin, and the results of this clinical intervention are described. In five cases there was no untoward deterioration of the mental state, in three cases a change was reversed by judicious adjustment of both the anticonvulsant and psychotropic medications. Recommendations for the use of...
This 29-year-old woman with a history of major depression and poorly controlled complex partial and secondarily generalized seizures presented with disorientation, agitation, and hyperreligiosity after six generalized convulsive seizures. During psychosis, electroencephalography revealed waxing and waning periodic sharp waves over the left temporal region, which disappeared after the resolution of...
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